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AUA risk stratification for primary non-muscle invasive bladder cancer

AUA risk stratification for primary non-muscle invasive bladder cancer
Low risk
  • Papillary urothelial neoplasm of low malignant potential
  • Low-grade solitary Ta tumor ≤3 cm in diameter
Intermediate risk
  • Low-grade Ta and recurrence within 1 year
  • Low-grade solitary Ta tumor >3 cm
  • Low-grade multifocal Ta
  • First occurrence, solitary, high-grade Ta tumor ≤3 cm in diameter
  • Low-grade T1
High risk
  • High-grade T1
  • Any recurrent high-grade Ta
  • High-grade Ta tumor >3 cm or multifocal
  • Any CIS
  • Any BCG failure in a patient with high-grade tumor
  • Any variant histology
  • Any lymphovascular invasion
  • Any high-risk prostatic urethral involvement
AUA: American Urologic Association; BCG: Bacille Calmette-Guérin; CIS: carcinoma in situ.
Reproduced with permission from: Holzbeierlein JM, Bixler BR, Buckley DI, et al. Diagnosis and treatment of non-muscle invasive bladder cancer: AUA/SUO guideline: 2024 Amendment. J Urol 2024; 211:533. Copyright © 2024 American Urological Association Education and Research, Inc.
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