Approach to genetic testing for suspected familial hyperaldosteronism

This algorithm summarizes our suggested approach to genetic testing in patients with suspected familial forms of primary aldosteronism. Familial hyperaldosteronism should only be considered in individuals with confirmed primary aldosteronism. The approach to case detection and confirmatory testing for primary aldosteronism is discussed separately in UpToDate.

* All 4 forms of familial hyperaldosteronism are inherited in an autosomal dominant pattern.

¶ A genetic testing panel is also available for familial hyperaldosteronism. The decision to perform targeted or broad genetic testing is based on cost, convenience, and clinical suspicion for a specific underlying form of familial hyperaldosteronism.

Δ Familial hyperaldosteronism type II is probably the most common form and is clinically indistinguishable from sporadic primary aldosteronism.

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خرید پکیج

Approach to genetic testing for suspected familial hyperaldosteronism