Summary of estrogens and progestin generations used in oral contraceptive pills

Lower doses of estrogen are associated with lower BP elevations. Drospirenone may have BP-lowering effects.^[1]

BP: blood pressure.

* Available as progestin-only pill.

¶ Coformulated with estradiol hemihydrate.

Δ Higher risk of venous thromboembolism when coadministered with ethinyl estradiol compared with their older counterparts.

◊ Associated with BP-lowering effects.

Reference:

de Souza IS, Laporta GZ, Zangirolami-Raimundo J, et al. Association between the use of oral contraceptives and the occurrence of systemic hypertension: A systematic review with statistical comparison between randomized clinical trial interventions. Eur J Obstet Gynecol Reprod Biol X 2024; 22:100307.

Reproduced with permission from Wolters Kluwer Health, Inc.: Cameron NA, Blyler CA, Bello NA. Oral contraceptive pills and hypertension: A review of current evidence and recommendations. Hypertension 2023; 80(5):924-935. Copyright © 2023 American heart Association, Inc. https://www.ahajournals.org/journal/hyp.

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Summary of estrogens and progestin generations used in oral contraceptive pills