Headache medications that can cause medication overuse headache

Risk of MOH	Medication class	Exposure frequency that may constitute overuse
High	Barbiturates	≥10 days/month^*
	Opioids
	Triptans
Moderate	Combination analgesics (eg, acetaminophen-aspirin-caffeine)	≥10 days/month
	Ergotamines
	Lasmiditan
	Multiple medications/combination therapy
Low	Nonsteroidal antiinflammatory drugs (eg, ibuprofen)	≥15 days/month
	Acetaminophen

Several medications used for acute (symptomatic) headache treatment may cause MOH when used to excess. The threshold of use that confers the risk of developing MOH varies by class of medication, duration of use, and individual behavioral factors. Refer to UpToDate for additional details.

MOH: medication overuse headache.

* Clinical experience suggests even lower thresholds of monthly exposure to barbiturates and opioids may cause MOH. Use of these medication classes for the treatment of primary headache should be avoided.

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Headache medications that can cause medication overuse headache