Medications associated with worsening LUTS (lower urinary tract symptoms)

Alzheimer disease medications: donepezil, amantadine

Anticholinergics: oxybutynin, inhaled anticholinergics for COPD

Antidepressants: tricyclic antidepressants, paroxetine, fluvoxamine, milnacipran

Antihistamines and decongestants: diphenhydramine, cimetidine, pseudoephedrine

Antiparkinson medications: levodopa

Antipsychotic medications: risperidone, levomepromazine

Benzodiazepines

Bronchodilators: tiotropium bromide

Diuretics

Sympathomimetics

This table lists the most commonly prescribed medication classes that may worsen LUTS. Potential alternative medications should be reviewed with the patient prior to adding medical therapy for LUTS. Please refer to related UpToDate content for additional detail.

COPD: chronic obstructive pulmonary disease.

Graphic 145515 Version 1.0

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Medications associated with worsening LUTS (lower urinary tract symptoms)