Version July 2025
HIV: human immunodeficiency virus infection; TB: tuberculosis; TBI: tuberculosis infection.
* We define a contact as an individual who shares an enclosed space with a patient with untreated respiratory TB disease for ≥4 hours per week.
¶ High TB incidence settings may be defined as those with TB incidence of ≥40 per 100,000. Refer to UpToDate topic on diagnosis of TBI in children for further discussion.
Δ Children <5 years of age with recent TB exposure are at relatively high risk for progression to TB disease, and the child's cellular immune response to TB may not have fully developed at the time of testing.