Apoptotic neutrophils in the peripheral blood of a patient with MDS

Apoptosis is a form of programmed cell death that may be seen in MDS with cytopenias. These images are from the peripheral blood smear of a patient who presented with anemia and thrombocytopenia; bone marrow aspirate and biopsy confirmed the diagnosis of MDS with multilineage dysplasia. The peripheral blood smear demonstrated neutrophils undergoing progressive stages of apoptosis (arrows).

(A) Chromatin condensation in a neutrophil with cell shrinkage
(B, C) Disintegration of the neutrophil nucleus and organelles
(D) Formation of an apoptotic body in a neutrophil

MDS: myelodysplastic syndrome.

Used with permission of the American Society of Hematology, from: Chin-Yee I, Thiyagarajah K. Apoptotic neutrophil in peripheral blood of a patient with myelodysplastic syndrome (MDS). ASH Image Bank 2017; permission conveyed through Copyright Clearance Center, Inc. https://imagebank.hematology.org/image/61103 (Accessed on September 10, 2024).

Graphic 145926 Version 1.0

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Apoptotic neutrophils in the peripheral blood of a patient with MDS