Strategies for resuming a GLP-1 receptor agonist-based agent after a prolonged lapse in therapy

1.5 mg once weekly

• Resume at 1.5 mg once-weekly dose.
• Expect comparable tolerability to that experienced prior to dose interruption.
• Use best judgment if ≥3 doses are missed.
  • It is unknown whether tolerance to the GI adverse events will remain if reinitiated at the higher dose after ≥3 missed doses.
  • Decision can be informed by patient's prior GI tolerability.
  • In consideration of the above, clinicians may consider reinitiating at 1.5 mg once weekly.

• If ≤2 doses are missed, reinitiate at 1 mg once weekly.
• If 3 to 4 doses are missed, reinitiate at 0.5 mg weekly.
• If ≥5 doses are missed, reinitiate at 0.25 mg once weekly.

• If ≤2 doses are missed, reinitiate at the same dose (provided the dose was adequately tolerated).
• If ≥3 doses are missed, reinitiate at 5 mg once weekly.