| Agent | Last dose administered | Recommendation(s) for resuming therapy |
| Dulaglutide | 1.5 mg once weekly 3 or 4.5 mg once weekly | - Resume at 1.5 mg once-weekly dose.
- Expect comparable tolerability to that experienced prior to dose interruption.
- Use best judgment if ≥3 doses are missed.
- It is unknown whether tolerance to the GI adverse events will remain if reinitiated at the higher dose after ≥3 missed doses.
- Decision can be informed by patient's prior GI tolerability.
- In consideration of the above, clinicians may consider reinitiating at 1.5 mg once weekly.
|
| Injectable semaglutide | 1 mg once weekly | - If ≤2 doses are missed, reinitiate at 1 mg once weekly.
- If 3 to 4 doses are missed, reinitiate at 0.5 mg weekly.
- If ≥5 doses are missed, reinitiate at 0.25 mg once weekly.
|
| Tirzepatide | ≥5 mg once weekly | - If ≤2 doses are missed, reinitiate at the same dose (provided the dose was adequately tolerated).
- If ≥3 doses are missed, reinitiate at 5 mg once weekly.
|
