Typical serological response in acute Q fever

IgM and then IgG antibodies develop to phase II antigens in 10 to 14 days from symptom onset. Seroconversion or a fourfold rise in phase II IgG or CFT titer in convalescent serum is diagnostic of Q fever.

CFT: complement fixation test; IFA: immunofluorescence assay; IgG: immunoglobulin G; IgM: immunoglobulin M; PCR: polymerase chain reaction.

* By IFA.

Adapted with permission from: Chaudhuri A, Robson J. Q fever queries and answers. Medicine Today 2013; 14(4): 54-59.

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Typical serological response in acute Q fever