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Cloxacillin (United States: Not available): Pediatric drug information

Cloxacillin (United States: Not available): Pediatric drug information
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For additional information see "Cloxacillin (United States: Not available): Drug information" and "Cloxacillin (United States: Not available): Patient drug information"

For abbreviations, symbols, and age group definitions show table
Brand Names: Canada
  • JAMP-Cloxacillin;
  • TEVA-Cloxacillin
Therapeutic Category
  • Antibiotic, Penicillin
Dosing: Neonatal

Dosage guidance:

Dosage form information: Not available in the United States.

General dosing:

Weight-directed dosing (Ref): Limited data available:

Preterm and term neonates: IV:

Note: Use the higher end of the dosing range for meningitis (Ref).

Cloxacillin Weight-Directed Neonatal Dosing

Body weight

Postnatal age

Dose

<2 kg

≤7 days

25 to 50 mg/kg/dose every 12 hours

8 to 28 days

25 to 50 mg/kg/dose every 8 hours

≥2 kg

≤7 days

25 to 50 mg/kg/dose every 8 hours

8 to 28 days

25 to 50 mg/kg/dose every 6 hours

Age-directed dosing (Ref): Limited data available:

Preterm and term neonates: IV:

Cloxacillin Age-Directed Neonatal Dosing

Postnatal age

Dose

<7 days

25 to 50 mg/kg/dose every 12 hours

7 to <21 days

25 to 50 mg/kg/dose every 8 hours

21 to 28 days

25 to 50 mg/kg/dose every 6 to 8 hours

Dosing: Pediatric

Dosage guidance:

Dosage form information: Not available in the United States.

General dosing:

Note: Doses are presented in mg/kg or fixed mg doses depending on weight; use caution. Duration depends on patient-specific factors including site of infection and clinical response.

Oral: Children and Adolescents (Ref):

5 to <40 kg: Oral: 50 mg/kg/day in divided doses every 6 hours.

≥40 kg: Oral: 250 to 500 mg every 6 hours. For very severe infections, higher doses may be required; maximum daily dose: 6,000 mg/day.

Parenteral: Infants, Children, and Adolescents: IV, IM: 100 to 200 mg/kg/day in divided doses every 6 hours (Ref); maximum dose: 2,000 mg/dose (Ref).

Endocarditis

Endocarditis (methicillin-susceptible Staphylococcus aureus): Children and Adolescents: IV: 200 to 300 mg/kg/day divided every 4 to 6 hours (Ref); maximum dose: 2,000 mg/dose (Ref). Recommended treatment duration is 4 to 6 weeks for native valve endocarditis and ≥6 weeks (as part of an appropriate combination regimen) for prosthetic valve endocarditis (Ref).

Osteoarticular infection, acute

Osteoarticular infection, acute (eg, bacterial arthritis, osteomyelitis):

IV: Children and Adolescents: IV: 100 to 200 mg/kg/day in divided doses every 4 to 6 hours (Ref); maximum dose: 2,000 mg/dose (Ref); maximum daily dose: 12,000 mg/day (Ref). May transition to oral therapy as appropriate (eg, following initial response to parenteral therapy, tolerating oral intake) (Ref).

Oral step-down therapy: Children and Adolescents: Oral: 100 mg/kg/day in divided doses every 6 hours; maximum dose: 1,000 mg/dose (Ref).

Duration of therapy: Minimum total duration is 10 to 14 days for bacterial arthritis and 21 to 28 days for osteomyelitis; however, duration may be longer and should be individualized based on several factors, including causative pathogen, response to therapy, and normalization of inflammatory markers (Ref).

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Liver Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Adult

(For additional information see "Cloxacillin (United States: Not available): Drug information")

Note: Dose and duration of therapy can vary depending on infecting organism, severity of infection, and clinical response of patient. Treat severe staphylococcal infections for at least 14 days; endocarditis and osteomyelitis require an extended duration of therapy for 4 to 6 weeks. The intravenous route should be used for severe infections.

Usual dosage range:

Oral: 250 to 500 mg every 6 hours; may increase dose for serious infections (maximum dose: 6 g/day).

IM, IV: 1 to 2 g every 4 to 6 hours (Ref).

Bloodstream infection due to methicillin-susceptible Staphylococcus aureus

Bloodstream infection due to methicillin-susceptible Staphylococcus aureus: IV: 2 g every 4 to 6 hours (Ref); treat uncomplicated S. aureus bacteremia for ≥14 days starting from day of first negative blood culture, with longer courses warranted for endocarditis or metastatic sites of infection (Ref).

Endocarditis due to methicillin-susceptible staphylococci

Endocarditis due to methicillin-susceptible staphylococci:

Native valve: IV: 12 g/day in 4 to 6 divided doses for 4 to 6 weeks (Ref).

Prosthetic valve: IV: 12 g/day in 4 to 6 divided doses for ≥6 weeks, in combination with rifampin and gentamicin (Ref).

Osteomyelitis due to methicillin-susceptible Staphylococcus aureus

Osteomyelitis due to methicillin-susceptible Staphylococcus aureus: IV: 2 g every 4 hours for ≥6 weeks (Ref).

Skin and soft tissue infection

Skin and soft tissue infection:

Localized purulent skin lesions, impetigo: Oral: 250 to 500 mg every 6 hours for 5 to 7 days (Ref).

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Adult

The renal dosing recommendations are based upon the best available evidence and clinical expertise. Senior Editorial Team: Bruce Mueller, PharmD, FCCP, FASN, FNKF; Jason A. Roberts, PhD, BPharm (Hons), B App Sc, FSHP, FISAC; Michael Heung, MD, MS.

Kidney impairment prior to treatment initiation:

Altered kidney function:

Oral: No dosage adjustment necessary.

IV:

CrCl ≥10 mL/minute: No dosage adjustment necessary.

CrCl <10 mL/minute: No specific dosage adjustment recommended; however, monitor patients closely as studies conducted in critically ill patients with severe kidney impairment have found supratherapeutic cloxacillin concentrations (eg, >100 mg/L) in this population as well as neurotoxicity and nephrotoxicity (Ref). When treating less severe infections, consider limiting dose to 8 g/day (Ref).

Hemodialysis, intermittent (thrice weekly): Not significantly dialyzed (Ref):

Oral, IV: Dose as per CrCl <10 mL/minute (Ref).

Peritoneal dialysis: Unlikely to be significantly dialyzed (highly protein bound) (Ref):

Oral, IV: Dose as per CrCl <10 mL/minute (Ref).

CRRT:

Note: Drug clearance is dependent on the effluent flow rate, filter type, and method of renal replacement. Recommendations are based on high-flux dialyzers and effluent flow rates of 20 to 25 mL/kg/hour (or ~1,500 to 3,000 mL/hour) and minimal residual kidney function unless otherwise noted. Appropriate dosing requires consideration of adequate drug concentrations (eg, site of infection). Close monitoring of response and adverse reactions (eg, neurotoxicity) due to drug accumulation is important.

Oral, IV: No dosage adjustment necessary (Ref).

PIRRT (eg, sustained, low-efficiency diafiltration):

Note: Drug clearance is dependent on the effluent flow rate, filter type, and method of renal replacement. Appropriate dosing requires consideration of adequate drug concentrations (eg, site of infection). Close monitoring of response and adverse reactions (eg, neurotoxicity) due to drug accumulation is important.

Oral, IV: No dosage adjustment necessary (Ref).

Nephrotoxicity during treatment: Nephrotoxicity has been reported with cloxacillin use, particularly in patients receiving high-dose IV therapy (eg, ≥8 g per day). Risk factors include older age (eg, >75 years of age) and concomitant use of other nephrotoxins. If acute kidney injury occurs, discontinue cloxacillin and administer an alternate antibiotic (Ref).

Dosing: Liver Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Adverse Reactions

The following adverse drug reactions are derived from product labeling unless otherwise specified. Reactions listed are based on reports for other agents in this same pharmacologic class and may not be specifically reported for cloxacillin.

Postmarketing:

Cardiovascular: Thrombophlebitis (IV)

Dermatologic: Acute generalized exanthematous pustulosis (Choon 2018), erythematous maculopapular rash (Moreno-Ancillo 2003)

Endocrine & metabolic: Hypokalemia (Nagasayi 2017)

Gastrointestinal: Clostridioides difficile colitis, diarrhea, epigastric discomfort, esophagitis (Zezos 2016), flatulence, hairy tongue, loose stools, nausea, stomatitis, vomiting (St John 1981)

Genitourinary: Hematuria (St John 1981)

Hematologic & oncologic: Agranulocytosis (Mani 2017), anemia, eosinophilia (Jayaweera 2018), granulocytopenia, hemolytic anemia, immune thrombocytopenia, leukopenia (St John 1981), neutropenia (Jayaweera 2018), thrombocytopenia

Hepatic: Cholestatic hepatitis (Goland 1998), cholestatic jaundice (Enat 1980), hepatic disease (vanishing bile duct syndrome) (Faragalia 2022), hepatotoxicity, increased serum alkaline phosphatase, increased serum transaminases (including increased serum alanine aminotransferase and increased serum aspartate aminotransferase) (St. John 1981)

Hypersensitivity: Anaphylaxis, angioedema, hypersensitivity angiitis (Garcia-Porrua 1999), hypersensitivity reaction (Rodriguez-Jimenez 2009), type IV hypersensitivity reaction (Moreno-Ancillo 2003)

Renal: Interstitial nephritis (Grimm 1989) renal tubular disease

Miscellaneous: Fever

Contraindications

Hypersensitivity to cloxacillin, other penicillins, cephalosporins, or any component of the formulation

Warnings/Precautions

Concerns related to adverse effects:

• Anaphylactoid/hypersensitivity reactions: Serious and occasionally severe or fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy, especially with a history of beta-lactam hypersensitivity, history of sensitivity to multiple allergens, or previous IgE-mediated reactions (eg, anaphylaxis, angioedema, urticaria). Use with caution in asthmatic patients.

• CNS effects: Although not reported with cloxacillin, the transport of penicillins across the blood-brain barrier may be enhanced by inflamed meninges or during cardiopulmonary bypass. An increased risk of myoclonia, seizures, or reduced consciousness may be observed in these patients (particularly those with renal failure).

• Hematologic effects: Penicillin use has been associated with hematologic disorders (eg, agranulocytosis, neutropenia, thrombocytopenia) believed to be a hypersensitivity phenomena. Reactions are most often reversible upon discontinuing therapy.

• Superinfection: Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment.

Disease-related concerns:

• Renal impairment: Use with caution in patients with renal impairment; rate of elimination is reduced.

• Seizure disorders: Use with caution in patients with a history of seizure disorder; high serum levels, particularly in the presence of renal impairment, may increase risk for seizures.

Special populations:

• Neonates: May have decreased renal clearance of cloxacillin; frequent evaluation of serum levels and of clinical status for adverse effects as well as frequent dosage adjustments may be necessary in this patient population.

Product Availability

Not available in the US

Generic Equivalent Available: US

Yes

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral:

Generic: 250 mg, 500 mg

Solution Reconstituted, Injection:

Generic: 500 mg (1 ea); 1 g (1 ea); 2 g (1 ea); 10 g (1 ea)

Suspension Reconstituted, Oral:

Generic: 125 mg/5 mL (60 mL, 100 mL, 200 mL)

Administration: Pediatric

Oral: Administer 1 to 2 hours before meals.

Oral solution: Shake well. Administer liquid with an accurate measuring device; do not use a household teaspoon (under- or overdosage may occur).

Parenteral:

IM: Administer in appropriate anatomical site for age.

IV push: Administer slowly over 2 to 4 minutes.

IV infusion: Administer over 30 to 60 minutes (Ref).

Administration: Adult

Oral: Administer with water 1 hour before or 2 hours after meals.

IV:

IV push: Administer slowly over 2 to 4 minutes.

IV infusion: Administer over 30 to 40 minutes.

Storage/Stability

Capsule: Store at room temperature not exceeding 25°C (77°F).

Powder for injection: Store at controlled room temperature 15°C to 30°C (59°F to 86°F). Upon reconstitution the resulting solution is stable for up to 24 hours at controlled room temperature not exceeding 25°C (77°F) or up to 48 hours under refrigeration 2°C to 8°C (36°F to 46°F).

IV infusion: Note: After reconstitution of powder with appropriate volume of sterile water for injection, the manufacturer suggests further dilution to concentrations of 1 to 2 mg/mL in a compatible solution (eg, D5W, NS); solutions are stable for up to 12 hours at controlled room temperature.

Powder for oral solution: Prior to mixing, store powder at room temperature not exceeding 25°C (77°F). Refrigerate oral solution after reconstitution; discard after 14 days.

Use

Note: Not approved in the United States.

Canadian labeling: Treatment of streptococcal and staphylococcal infections (indicated in children and adults).

Metabolism/Transport Effects

Substrate of OAT1/3;

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program

Acemetacin: May increase serum concentration of Penicillins. Risk C: Monitor

Aminoglycosides: Penicillins may decrease serum concentration of Aminoglycosides. Primarily associated with extended spectrum penicillins, and patients with renal dysfunction. Risk C: Monitor

Bacillus clausii: Antibiotics may decrease therapeutic effects of Bacillus clausii. Management: Bacillus clausii should be taken in between antibiotic doses during concomitant therapy. Risk D: Consider Therapy Modification

BCG (Intravesical): Antibiotics may decrease therapeutic effects of BCG (Intravesical). Risk X: Avoid

BCG Vaccine (Immunization): Antibiotics may decrease therapeutic effects of BCG Vaccine (Immunization). Risk C: Monitor

Cholera Vaccine: Antibiotics may decrease therapeutic effects of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Risk X: Avoid

Dichlorphenamide: Penicillins may increase hypokalemic effects of Dichlorphenamide. Risk C: Monitor

Fecal Microbiota (Live) (Oral): May decrease therapeutic effects of Antibiotics. Risk X: Avoid

Fecal Microbiota (Live) (Rectal): Antibiotics may decrease therapeutic effects of Fecal Microbiota (Live) (Rectal). Risk X: Avoid

Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies): Antibiotics may decrease therapeutic effects of Immune Checkpoint Inhibitors (Anti-PD-1, -PD-L1, and -CTLA4 Therapies). Risk C: Monitor

Lactobacillus and Estriol: Antibiotics may decrease therapeutic effects of Lactobacillus and Estriol. Risk C: Monitor

Methotrexate: Penicillins may increase serum concentration of Methotrexate. Risk C: Monitor

Mycophenolate: Antibiotics may decrease active metabolite exposure of Mycophenolate. Specifically, concentrations of mycophenolic acid (MPA) may be reduced. Risk C: Monitor

Probenecid: May increase serum concentration of Penicillins. Risk C: Monitor

Sodium Benzoate: Penicillins may decrease therapeutic effects of Sodium Benzoate. Risk C: Monitor

Sodium Picosulfate: Antibiotics may decrease therapeutic effects of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Risk D: Consider Therapy Modification

Tetracyclines: May decrease therapeutic effects of Penicillins. Risk C: Monitor

Typhoid Vaccine: Antibiotics may decrease therapeutic effects of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Avoid use of live attenuated typhoid vaccine (Ty21a) in patients being treated with systemic antibacterial agents. Postpone vaccination until 3 days after cessation of antibiotics and avoid starting antibiotics within 3 days of last vaccine dose. Risk D: Consider Therapy Modification

Vancomycin: Cloxacillin may increase nephrotoxic effects of Vancomycin. Risk C: Monitor

Vitamin K Antagonists: Cloxacillin may decrease anticoagulant effects of Vitamin K Antagonists. Cloxacillin may increase anticoagulant effects of Vitamin K Antagonists. Risk C: Monitor

Food Interactions

Food decreases cloxacillin absorption; serum levels are reduced by ~50%. Management: Administer with water on an empty stomach 1 hour before or 2 hours after meals.

Pregnancy Considerations

Penicillin class antibiotics cross the placenta in varying degrees. Cloxacillin is highly protein bound which may influence fetal exposure (Nau 1987).

As a class, penicillin antibiotics are widely used in pregnant women. Based on available data, penicillin antibiotics are generally considered compatible for use during pregnancy (Ailes 2016; Bookstaver 2015; Crider 2009; Damkier 2019; Lamont 2014; Muanda 2017a; Muanda 2017b).

Monitoring Parameters

CBC with differential, kidney and liver function tests; observe for changes in bowel frequency. Monitor for hypersensitivity (including anaphylaxis).

Mechanism of Action

Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Oral: ~50%; reduced by food

Distribution: Widely to most body fluids and bone; penetration into cells, into eye, and across normal meninges is poor; inflammation increases amount that crosses blood-brain barrier

Protein binding: ~94% (primarily albumin)

Metabolism: Hepatic to active and inactive metabolites

Half-life elimination: 0.5 to 1.5 hours; prolonged with renal impairment and in neonates

Time to peak, serum: Oral: ~1 hour

Excretion: Urine and feces

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Monoclox | Orbenin;
  • (BD) Bangladesh: A-Clox | Adclox | Aldaclox | Ambeeclox | Aristoclox | Bactaclox | Betaclox | Biclox | Bitacep | Bpclox | Clobex | Cloxa | Cloxapen | Cloxi-Z | Cloxicap | Cloxiject | Cloxil | Cloxilin | Cloxima | Cloxin | Cloxisyrup | Cloxpen | Eclox | Ficlox | G-cloxacillin | Hi-Clox | Jp clox | Loxacin | Lysiclox | Miclocin | Navaclox | Neuclox | Omniclox | Penclox | Reclox | Remaclox | Simpiclox | Sinaclox | T-Clox | Tyclox | Ultraclox | Xeclox;
  • (BE) Belgium: Orbenin | Penstaphon;
  • (BF) Burkina Faso: Cloxacilline;
  • (BG) Bulgaria: Cloxacillin;
  • (BR) Brazil: Bactopen;
  • (CH) Switzerland: Orbenin;
  • (CI) Côte d'Ivoire: Caxol;
  • (CL) Chile: Cloxacilina;
  • (CN) China: Ao ge lin | Cloxacillin | Gao fen | Kai li | Kang ni li xing | Li da xin | Nuo kai | Pu kang bei | Rui pu lin | Tang nuo | Ya jun lin | Zhan ning;
  • (CO) Colombia: Prostafilina a;
  • (EE) Estonia: Orbenil;
  • (ES) Spain: Anaclosil | Cloxacilina Ips | Cloxacilina normon | Orbenin;
  • (ET) Ethiopia: Clox | Cloxacillin;
  • (FI) Finland: Cloxacillin navamedic | Cloxacillin vital pharma nordic | Ekvacillin | Staflocil;
  • (FR) France: Cloxacillin sandoz | Cloxacilline arrow | Cloxacilline biogaran | Cloxacilline eg | Cloxacilline mylan | Cloxacilline panpharma | Cloxacilline stragen | Cloxacilline zentiva | Cloxypen | Orbenine | Staphybiotic;
  • (GB) United Kingdom: Cloxacillin | Cloxacillin cox | Orbenin;
  • (GR) Greece: Anaclosil | Cloxacillin/Remedica | Orbenin | Staphyclox;
  • (HK) Hong Kong: Apo-cloxi | Cloxa | Cloxacap | Cloxacillin | Cloxacin | Lidoxin | Monoclox | Orbenin | Syncillin;
  • (HR) Croatia: Orbenin;
  • (ID) Indonesia: Ikaclox | Meixam | Orbenin;
  • (IE) Ireland: Orbenin;
  • (IL) Israel: Loxavit | Orbenil;
  • (IN) India: Bioclox | Clin | Clopen | Cloxacillin | Cloxin | Klox | Nexiclox ds | Staphnil;
  • (JO) Jordan: Monoclox | Prostaphlin A;
  • (JP) Japan: Methocillin s | Orbenin;
  • (KE) Kenya: Cloxacillin | Cloxispa | Dawaclox | Kloxy | Mediclox | Nelox;
  • (KR) Korea, Republic of: Orbrex;
  • (KW) Kuwait: Monoclox | Orbenin;
  • (LB) Lebanon: Cloxacil | Cloxacillin | Cloxacilline | Cloxacilline arrow | Orbenin | Prostaphlin A;
  • (LT) Lithuania: Cloxacillin | Syntarpen;
  • (LU) Luxembourg: Orbenin;
  • (LV) Latvia: Cloxacillin;
  • (MY) Malaysia: Axocillin | Cloxa | Cloxabiotic | Cloxacap | Cloxacilla | Cloxacillin | Cloxacillin Pharmaniaga | Cloxcin | Cloxicap | Cloxil | Cloxillin | Dyna Cloxacillin | Isoxacillin | Loxamycin | Monoclox;
  • (NG) Nigeria: Cloxacillin;
  • (NL) Netherlands: Cloxacilline gf | Orbenin;
  • (NO) Norway: Cloxacillin | Cloxacillin navamedic | Cloxacillin navamedic nordic | Cloxacillin stragen | Cloxacillin villerton | Ekvacillin;
  • (OM) Oman: Cloxadar;
  • (PE) Peru: Cloxacilina | Prostafilina a;
  • (PH) Philippines: Avastoph | Axillin | Boie cloxacillin | Caxin | Ciclox | Cillox | Clocsamed | Clofinil | Clonacil | Clopen | Clovex | Clox | Cloxacillin | Cloxacillin Diamond | Cloxacillin Interpharm | Cloxacillin Sydenham | Cloxacin | Cloxakid | Cloxal | Cloxalin | Cloxceena | Cloxid | Cloxigen | Cloxil | Cloxin | Cloxipen | Corstaph | Cyclox | Diacil | Diaclox | Dialox | Eloxil | Encloxil | Eraclox | Farmclox | Flactamacin | Kloxitas | Lewinex | Medaclox | Mediclox | Medix | Myreclox | Nacloxin | Nalixol | Nocloxol | Orbenin | Oxaclen | Oxeed | Pannox | Patriflex | Pharex cloxacillin | Prostaphlin A | RiteMED Cloxacillin | Secloxin | Solaze | Sydenclox | Vamcloxil | Vivarin | Zeflodan;
  • (PK) Pakistan: Auropen | Boschoclox | Cloxcin | Loxacin | Novoclox | Orbenin | Tabroclox;
  • (PL) Poland: Syntarpen;
  • (QA) Qatar: Klox | Monoclox;
  • (SA) Saudi Arabia: Monoclox | Orbenin;
  • (SE) Sweden: Cloxacillin navamedic | Cloxacillin stragen | Cloxacillin vital pharma nordic | Ekvacillin;
  • (SG) Singapore: Apo-cloxi | Axocillin | Cloxacap | Cloxacillin | Cloxacillin stragen | Cloxcin | Cloxillin | Lidoxin | Monoclox | Orbenin | Procap-C;
  • (SI) Slovenia: Anaclosil | Cloxacilina normon | Cloxacillin stragen | Orbenin;
  • (SL) Sierra Leone: Cloxacillin;
  • (TH) Thailand: Axocillin | C Cloxa | Cloxa | Cloxa m h | Cloxa T M N | Cloxacan | Cloxacap | Cloxacel | Cloxacillin | Cloxalin | Cloxam | Cloxamed | Cloxan | Cloxanbin | Cloxano | Cloxapan | Cloxasian | Cloxasin | Cloxasol | Cloxatin | Cloxcillin | Cloxcin | Cloxgen | Cloxil | Cloxin | Cloxino | Cloxlin | Cloxolen | Cloxomed | Cloxpac | Cloxstar | Coclox | Corbin | Greater-gloxa | K-cil | Kressxalin | Lidoxin | Lincox | Loxzalin | Medcloxa | Meiclox | Monoclox | Orbenin | Panoxilin | Pharclox | Pinclox | S Cloxin | Serviclox | Sinocloxin | Socloxin | Specclox | Staphoclox | Syntoclox | Theraclox | Ticlox | Vaclox | Vicloxa | Xalin;
  • (TW) Taiwan: Cloxacillin | Orbenin | Prostaphlin A;
  • (UG) Uganda: Agoclox | Alclox | Bruclox | Cloxacillin | Cloxaren | Cloxcin | Cloxin | Cloxispa | Dawaclox | Kamcloxa | Kloxy | Uclox;
  • (VE) Venezuela, Bolivarian Republic of: Orbenin;
  • (ZA) South Africa: Cloxacillin fresenius | Cloxin | Orbenin | Rolab-cloxacillin;
  • (ZM) Zambia: Alclox | Cloxacillin | Cloxafil | Cloxasafe | Cloxil | Cloxin | Cloxispa | Klox | Symaclox;
  • (ZW) Zimbabwe: Cloxacillin | Iclox
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