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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 2 مورد

Treatment approaches for pediatric low-grade gliomas

Treatment approaches for pediatric low-grade gliomas
Molecular alteration First-line treatment options Relapsed/progressive treatment options
BRAF V600E Chemotherapy
  • Carboplatin/vincristine (CV)

Targeted therapy

  • Dabrafenib/trametinib

Clinical trials

  • NCT05566795
    • Tovorafenib versus CV or Vinblastine
 Chemotherapy
  • Carboplatin/vincristine (CV)
  • Vinblastine monotherapy
  • Thioguanine/procarbazine/lomustine/vincristine (TPCV)
  • Carboplatin monotherapy
  • Bevacizumab +/– irinotecan
  • Temozolomide +/– CV

Targeted therapy

  • Vemurafenib or dabrafenib
  • Tovorafenib
  • Selumetinib
  • Trametinib +/– dabrafenib

Radiation therapy
BRAF fusions Chemotherapy
  • Carboplatin/vincristine (CV)

Clinical trials

  • NCT04166409 – COG ACNS1833
    • Selumetinib versus CV
  • NCT05566795
    • Tovorafenib versus CV or Vinblastine
  • NCT04923126 – SJ901
    • Mirdametinib
 Chemotherapy
  • Carboplatin/vincristine (CV)
  • Vinblastine monotherapy
  • Thioguanine/procarbazine/lomustine/vincristine (TPCV)
  • Carboplatin monotherapy
  • Bevacizumab +/– irinotecan
  • Temozolomide +/– CV

Targeted therapy

  • Tovorafenib
  • Selumetinib
  • Trametinib

Radiation therapy

Clinical trials

  • NCT03363217 – TRAM-01
    • Trametinib
  • NCT04576117 – COG ACNS1931
    • Selumetinib versus selumetinib + vinblastine
  • NCT04923126 – SJ901
    • Mirdametinib
Neurofibromatosis type 1 (NF1) Chemotherapy
  • Carboplatin/vincristine (CV)

Clinical trials

  • NCT03871257 – COG ACNS1831
    • Selumetinib versus CV
  • NCT04923126 – SJ901
    • Mirdametinib
 Chemotherapy
  • Carboplatin/vincristine (CV)
  • Vinblastine monotherapy
  • Thioguanine/procarbazine/lomustine/vincristine (TPCV)
  • Carboplatin monotherapy
  • Bevacizumab +/– irinotecan

Targeted therapy

  • Selumetinib or trametinib

Clinical trials

  • NCT03363217 – TRAM-01
    • Trametinib
  • NCT04923126 – SJ901
    • Mirdametinib
Other alterations
(eg, FGFR1/2/3, NTRK, ROS1, ALK)		 Chemotherapy
  • Carboplatin/vincristine (CV)

Targeted therapy

  • Selumetinib

Clinical trials

  • NCT04923126 – SJ901
    • Mirdametinib
 Chemotherapy
  • Carboplatin/vincristine (CV)
  • Vinblastine monotherapy
  • Thioguanine/procarbazine/lomustine/vincristine (TPCV)
  • Carboplatin monotherapy
  • Bevacizumab +/– irinotecan
  • Temozolomide +/– CV

Targeted therapy

  • Selumetinib or trametinib
  • Everolimus

Radiation therapy

Clinical trials

  • NCT04576117 – COG ACNS1931
    • Selumetinib versus selumetinib + vinblastine
  • NCT04923126 – SJ901
    • Mirdametinib
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