UpToDate خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده:
4
September 2025
Treatment of melioidosis consists of an intensive phase with parenteral antibiotics to prevent mortality from severe illness followed by an eradication phase with oral antibiotics to prevent relapse. For initial intensive therapy, we recommend intravenous ceftazidime or an intravenous carbapenem, with or without adjunctive TMP-SMX, which can be administered intravenously or orally. This algorithm illustrates our approach to regimen selection based on severity and site of illness.
Refer to other UpToDate content for details on drug dosing and duration.
G-CSF: recombinant human granulocyte-colony stimulating factor; ICU: intensive care unit; TMP-SMX: trimethoprim-sulfamethoxazole.
* Supporting data for G-CSF are limited and some experts choose not to use it; it may also be inaccessible in some settings. If used, G-CSF is given for up to 10 days.
¶ Examples include bone or joint infection, vascular infection, and intraabdominal/pelvic abscesses. Certain foci of infection (eg, prostatic abscesses and mycotic aneurysms) warrant drainage or surgical intervention for cure; most other collections or abscesses generally resolve with medical therapy alone.
Δ The duration of intensive antibiotic therapy is at least 14 days, although longer durations may be warranted for certain severe or complicated manifestations. Following the intensive phase, we suggest transitioning all patients to oral TMP-SMX alone for the eradication phase.
◊ We consider patients to be improved once they no longer require intensive care.
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