Agents | Comments |
Age <2 months | |
Amoxicillin 10 to 15 mg/kg orally once daily | Switch to 1 of the agents below after 2 months of age For this age group, we use amoxicillin unless the infant has a penicillin allergy; cephalexin is a reasonable alternative |
Cephalexin 10 mg/kg orally once daily | |
Age ≥2 months | |
Trimethoprim-sulfamethoxazole 2 to 3 mg/kg trimethoprim component orally once daily (maximum 80 mg trimethoprim/dose) | Avoid in infants <2 months old (risk of hyperbilirubinemia due to hepatic immaturity) |
Nitrofurantoin 1 to 2 mg/kg orally once daily (maximum 100 mg/dose) | Avoid in infants <1 month old or children with G6PD deficiency (risk of hemolytic anemia) |
Trimethoprim (monotherapy) 1 to 3 mg/kg orally once daily (maximum 100 mg/dose) | Avoid in infants <1 month old An oral suspension is not commercially available but may be compounded from the tablets |
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