Condition | Deferral* |
Infectious risk factors | |
Diagnosis of AIDS or HIV infection; treatment with HIV antiretroviral therapy (ART) | Permanent |
Currently or previously confirmed positive for hepatitis B surface antigen (HBsAg) | Permanent |
Ever diagnosed with a prion disease (CJD, vCJD) or other transmissible encephalopathy | Permanent |
Ever received a cadaveric dura mater transplant | Permanent |
Ever received a xenotransplant (with the exception of porcine heart valves and porcine insulin) | Permanent |
Ever received bovine insulin or human growth hormone from cadaveric pituitary glands | Permanent |
Any blood relative with a heritable/genetic prion disease | Permanent |
Residence for >5 years in a malaria-endemic country (travel to a malaria-endemic country is listed below) | 3 years |
Malaria diagnosis | 3 years following recovery |
Babesiosis diagnosis or positive laboratory test | 2 years |
Hepatitis B immune globulin (HBIG) | 1 year |
Experimental vaccines | Up to 1 year |
Incarceration for at least 72 hours | 12 months |
Positive laboratory test for West Nile virus | 4 months (120 days) |
Close contact with someone who has viral hepatitis (HBV, HCV, or unknown source) | 3 months |
A new sexual partner or >1 sexual partner in the past 3 months and anal sex in the past 3 months | 3 months following the exposure |
Sex in exchange for money or drugs or sex with a commercial sex worker | 3 months |
Sex with a person who has ever had HIV or tested positive for HIV | 3 months |
Exposure to blood through needlestick injury or blood splash to mucous membrane or nonintact skin | 3 months |
Intravenous recreational drugs or sex with a person who used intravenous recreational drugs in the prior 3 months | 3 months |
Syphilis or gonorrhea | 3 months following treatment |
Blood transfusion | 3 months |
Solid organ transplant, allogeneic hematopoietic stem cell transplant, or allogeneic skin or bone graft | 3 months |
Body piercings or tattoos (except if performed in a licensed facility with sterile practices, in which case there is no deferral) | 3 months |
Travel to a malaria-endemic country for ≥24 hours (residence in a malaria-endemic country is listed above; travel of <24 hours is listed below) | 3 months |
Live attenuated vaccines:
| 4 weeks |
Live attenuated vaccines¶:
| 2 weeks |
Systemic antibiotics | Until course is completed |
Travel to a malaria-endemic country for <24 hours (deferrals for travel ≥24 hours and residence in a malaria-endemic country are listed above) | No deferral (unless feeling acutely ill) |
Toxoids, synthetic killed, or other noninfectious vaccines:
| No deferral (unless feeling acutely ill) |
Topical antibiotics for acne or rosacea | No deferral |
Noninfectious risk factors | |
Hematologic cancer | Typically indefinite (discretion of the blood center director) |
Nonhematologic cancer (except if localized and unable to spread hematogenously, such as cervical cancer in situ or basal cell skin cancer, in which case there is no deferral) | Typically 1 to 5 years after symptom free and considered cured (discretion of the blood center director) |
Neurodegenerative disease (Alzheimer disease, Parkinson disease) | Discretion of the blood center director |
Medications (includes those with risks for teratogenicity and bleeding and associated with certain infectious exposures) | Refer to separate UpToDate table |
AABB: Association for the Advancement of Blood and Biotherapies; AIDS: acquired immunodeficiency syndrome; CJD: Creutzfeldt-Jakob disease; COVID-19: coronavirus disease 2019; FDA: US Food and Drug Administration; HBV: hepatitis B virus; HCV: hepatitis C virus; HIV: human immunodeficiency virus; vCJD: variant Creutzfeldt-Jakob disease.
* Time-limited deferrals are based on the time since the exposure. Indefinite deferrals are for an unspecified period of time. Permanent deferral means the donor can never donate again. Refer to UpToDate for details and a discussion of the rationale.
¶ A live attenuated vaccine for COVID-19 has not been produced, but if it were to be produced, the deferral would be 2 weeks.
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