Clotrimazole (topical): Pediatric drug information

For additional information see "Clotrimazole (topical): Drug information" and "Clotrimazole (topical): Patient drug information"

For abbreviations, symbols, and age group definitions show table

Brand Names: US

3 Day Vaginal [OTC];
Alevazol [OTC];
Antifungal (Clotrimazole) [OTC];
Antifungal Clotrimazole [OTC] [DSC];
Clotrimazole 3 Day [OTC];
Desenex [OTC];
GoodSense Athletes Foot [OTC];
Gyne-Lotrimin 3 [OTC] [DSC];
Gyne-Lotrimin [OTC] [DSC];
Micotrin AC [OTC];
Mycozyl AC [OTC];
Pro-Ex Antifungal [OTC];
Shopko Athletes Foot [OTC] [DSC];
TM-Clotrimazole [OTC];
Trimazole [OTC];
Votriza-AL [OTC] [DSC]

Brand Names: Canada

Canesten;
Canesten 1 Day;
Canesten 3 Day;
Canesten 6 Day;
Canesten Combi 1 Day;
Canesten Combi 3 Day;
Canesten External Antifungal;
Canesten Extra Strength External Antifungal;
Clotrimaderm Topical

Therapeutic Category

Antifungal Agent, Topical;
Antifungal Agent, Vaginal

Dosing: Pediatric

Candidiasis, vulvovaginal

Candidiasis, vulvovaginal:

Children ≥12 years and Adolescents:

Cream: 1%: Intravaginal: Insert 1 applicatorful of 1% vaginal cream once daily (preferably at bedtime) for 7 consecutive days; some patients may require 14 days (Ref). May also apply externally twice daily for up to 7 days as needed for itching and irritation.

Cream: 1% (Canesten 6-day intravaginal cream 1% [Canadian product]): Intravaginal: Insert 1 applicatorful (~5 g) once daily (preferably at bedtime) for 6 consecutive days. May also apply externally twice daily for up to 7 days as needed for itching and irritation.

Cream: 2% (Canesten 3-day intravaginal cream 2% [Canadian product]): Intravaginal: Insert 1 applicatorful once daily (preferably at bedtime) for 3 consecutive days. May also apply externally twice daily for up to 7 days as needed for itching and irritation.

Cream: 10% (Canesten 1-day intravaginal cream 10% [Canadian product]): Intravaginal: Insert 1 applicatorful (~5 g) as a single dose (preferably at bedtime). May also apply 1% or 2% cream externally 1 to 2 times daily as needed for up to 7 days for itching and irritation.

Tablet (Canadian product): Note: When tablets are used in conjunction with an external cream (1% or 2%), apply cream 1 to 2 times/day as needed for up to 7 days for itching and irritation.

200 mg tablet: Intravaginal: Insert 1 vaginal tablet once daily for 3 days (preferably at bedtime).

500 mg tablet: Intravaginal: Insert 1 vaginal tablet as a single dose (preferably at bedtime).

Cutaneous candidiasis

Cutaneous candidiasis: Children ≥2 years and Adolescents: Topical ointment: 1%: Topical: Apply twice daily (morning and night) for 2 weeks.

Tinea corporis

Tinea corporis (ringworm): Children and Adolescents: Limited data available in ages <2 years: Topical cream, lotion, ointment, solution: 1%: Topical: Apply to affected and surrounding area(s) twice daily until clinical resolution, typically 2 to 4 weeks (Ref).

Tinea cruris

Tinea cruris (jock itch): Children and Adolescents: Limited data available in ages <2 years: Topical cream, lotion, ointment, solution: 1%: Topical: Apply to affected and surrounding area(s) twice daily until clinical resolution, typically 2 weeks (Ref).

Tinea pedis

Tinea pedis (athlete's foot): Children and Adolescents: Limited data available in ages <2 years: Topical cream, lotion, ointment, solution: 1%: Topical: Apply to affected and surrounding area(s) twice daily until clinical resolution, typically 4 weeks (Ref).

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely needed due to low systemic absorption.

Dosing: Liver Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely needed due to low systemic absorption.

Dosing: Adult

(For additional information see "Clotrimazole (topical): Drug information")

Candidiasis, vulvovaginal

Candidiasis, vulvovaginal: Note: A longer duration of 7 to 14 days may be necessary in patients with complicated infection (ie, recurrent or severe infection, infection with non-albicans Candida, pregnancy, or infection in an immunocompromised host) (Ref). Not effective against Candida glabrata (Ref).

Cream 1%: Intravaginal: Insert 1 applicatorful (~5 g) once daily (at bedtime) for 7 days (Ref). May also apply externally twice daily for 7 days, as needed, for itching and irritation.

Canesten 6-day intravaginal cream 1% [Canadian product]: Intravaginal: Insert 1 applicatorful (~5 g) once daily (at bedtime) for 6 days.

Cream 2%: Intravaginal: Insert 1 applicatorful (~5 g) once daily (at bedtime) for 3 days (Ref). May also apply externally twice daily for 7 days, as needed, for itching and irritation.

Cream 10% [Canadian product]: Intravaginal: Insert 1 applicatorful (~5 g) as a single dose (at bedtime). May also apply a thin layer of 1% or 2% cream externally to the irritated area 1 to 2 times/day, as needed, for up to 7 days.

Tablet [Canadian product]: Note: When tablets are used in conjunction with an external cream (1% or 2%), apply cream over the irritated area 1 to 2 times/day, as needed, for up to 7 days.

200 mg tablet: Intravaginal: Insert 1 vaginal tablet once daily for 3 days (at bedtime).

500 mg tablet: Intravaginal: Insert 1 vaginal tablet as a single dose (at bedtime).

Cutaneous candidiasis

Cutaneous candidiasis: Topical:

Cream 1%, solution 1%: Apply to affected area twice daily; if no improvement occurs after 4 weeks of therapy, re-evaluate diagnosis.

Ointment 1% (OTC labeling): Apply to affected area twice daily for 2 weeks.

Otomycosis

Otomycosis (off-label use): Topical: Solution 1%: Instill 4 to 5 drops into the affected ear(s) twice daily for 10 to 14 days (Ref); application should begin after thorough cleansing of the ear canal by the provider. Reassess after completion of therapy; if fungal elements are still present, repeat cleansing of the ear canal followed by another 10- to 14-day course of clotrimazole and reassessment. Several cycles of ear cleansing followed by topical therapy and reassessment may be required; persistent otomycosis should be managed by an otolaryngologist (Ref).

Tinea infection

Tinea infection:

Tinea corporis/tinea cruris (OTC labeling): Topical: Cream 1%, lotion 1%, ointment 1%, solution 1%: Apply to affected and surrounding area(s) twice daily until clinical resolution, typically 1 to 4 weeks (Ref).

Tinea pedis (OTC labeling)/tinea manuum (off-label use): Topical: Cream 1%, lotion 1%, ointment 1%, solution 1%: Apply to affected and surrounding area(s) twice daily until 1 week after clinical resolution, typically for 4 weeks total (Ref).

Tinea versicolor (pityriasis versicolor): Topical: Cream 1%, solution 1%: Apply to affected area(s) and immediate surrounding skin twice daily for 2 weeks (Ref).

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.

Dosing: Liver Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.

Adverse Reactions

The following adverse drug reactions are derived from product labeling unless otherwise specified.

Vaginal:

Postmarketing: Dermatologic: Burning sensation of skin, contact dermatitis (Abhinav 2015), contact hypersensitivity (Roller 1978), desquamation, erythema of skin, pruritus, skin blister, skin edema, skin irritation, stinging of the skin, urticaria

Contraindications

Hypersensitivity to clotrimazole or any component of the formulation.

OTC labeling: When used for self-medication, do not use vaginal cream if you have never had a vaginal yeast infection diagnosed by a doctor.

Warnings/Precautions

Concerns related to adverse effects:

• Local irritation: If irritation/sensitivity develops, discontinue therapy and institute appropriate alternative therapy.

Dosage form specific issues:

• Benzyl alcohol and derivatives: Some dosage forms may contain benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension and cardiovascular collapse (AAP ["Inactive" 1997]; CDC 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors 2001); avoid or use dosage forms containing benzyl alcohol with caution in neonates. See manufacturer's labeling.

Other warnings/precautions:

• Appropriate use: Topical: For external use only; avoid contact with the eyes. Not effective for treatment of scalp or nails. When used for self-medication, discontinue use and contact a healthcare provider if there is no improvement in 2 weeks (jock itch) or 4 weeks (athlete's foot, ringworm).

• Self-medication (OTC use): Vaginal: When used for self-medication (OTC), consult a health care provider before use if experiencing vaginal itching and discomfort for the first time, frequent vaginal yeast infections (eg, monthly, 3 in 6 months), or exposure to HIV. A mild increase in vaginal itching, burning, or irritation may occur with use; a health care provider should be consulted before switching to another agent if patient does not experience complete relief. Discontinue use and contact a health care provider if symptoms do not improve in 3 days or last more than 7 days, or if symptoms of a more serious condition occur (eg, abdominal pain, back/shoulder pain, fever, chills, nausea, vomiting, foul-smelling vaginal discharge). For vaginal use only; do not use tampons, douches, spermicides, or other vaginal products or have vaginal intercourse during treatment.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Cream, External:

Antifungal (Clotrimazole): 1% (14.2 g, 28.4 g, 113 g) [contains cetostearyl alcohol, methylparaben, propylene glycol, propylparaben]

Antifungal Clotrimazole: 1% (14 g [DSC], 28 g [DSC]) [contains cetyl alcohol, edetate (edta) trisodium, isopropyl alcohol, methylparaben, propylparaben, trolamine (triethanolamine)]

Clotrimazole GRx: 1% (14 g [DSC]) [contains benzyl alcohol, cetyl alcohol, polysorbate 80]

Desenex: 1% (30 g)

GoodSense Athletes Foot: 1% (14 g) [contains cetyl alcohol, edetate (edta) trisodium, isopropyl alcohol, methylparaben, propylparaben, trolamine (triethanolamine)]

Micotrin AC: 1% (85 g) [contains cetearyl alcohol, disodium edta, propylene glycol]

Mycozyl AC: 1% (85 g) [contains cetostearyl alcohol, disodium edta, glycerin (soy), propylene glycol]

Pro-Ex Antifungal: 1% (42 g) [contains cetyl alcohol, edetate (edta) trisodium, methylparaben, trolamine (triethanolamine)]

TM-Clotrimazole: 1% (30 g) [contains cetyl alcohol, edetate (edta) disodium, ethylparaben]

Generic: 1% (15 g, 28 g, 30 g, 45 g)

Cream, Vaginal:

3 Day Vaginal: 2% (21 g) [contains benzyl alcohol, cetyl alcohol]

Clotrimazole 3 Day: 2% (22.2 g)

Gyne-Lotrimin: 1% (45 g [DSC]) [contains benzyl alcohol]

Gyne-Lotrimin 3: 2% (21 g [DSC]) [contains benzyl alcohol, cetyl alcohol]

Generic: 1% (45 g), 2% (21 g)

Lotion, External:

Votriza-AL: 1% (30 mL) [contains cetearyl alcohol, trolamine (triethanolamine)]

Ointment, External:

Alevazol: 1% (56.7 g)

Solution, External:

Generic: 1% (10 mL, 29.57 mL, 30 mL)

Generic Equivalent Available: US

Yes

Pricing: US

Cream (Clotrimazole External)

1% (per gram): $0.37 - $1.16

Cream (Clotrimazole Vaginal)

1% (per gram): $0.11 - $0.18

Cream (Desenex External)

1% (per gram): $0.26

Cream (Micotrin AC External)

1% (per gram): $23.47

Cream (Mycozyl AC External)

1% (per gram): $23.47

Cream (Trimazole External)

1% (per gram): $11.71

Solution (Clotrimazole External)

1% (per mL): $0.59 - $16.16

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Cream, External:

Canesten: 1% (15 g, 30 g) [contains benzyl alcohol, cetostearyl alcohol]

Canesten External Antifungal: 1% (15 g) [contains benzyl alcohol, cetostearyl alcohol]

Canesten Extra Strength External Antifungal: 2% (15 g) [contains benzyl alcohol, cetostearyl alcohol]

Clotrimaderm Topical: 1% (20 g, 30 g, 50 g, 500 g) [contains benzyl alcohol, cetostearyl alcohol]

Generic: 1% (15 g, 30 g), 2% (15 g)

Cream, Vaginal:

Canesten 1 Day: 10% (5 g) [contains benzyl alcohol, cetostearyl alcohol]

Canesten 3 Day: 2% (25 g) [contains benzyl alcohol, cetostearyl alcohol]

Canesten 6 Day: 1% (50 g) [contains benzyl alcohol, cetostearyl alcohol]

Clotrimaderm Vaginal 3: 2% (25 g) [contains benzyl alcohol, cetostearyl alcohol]

Clotrimaderm Vaginal 6: 1% (50 g) [contains benzyl alcohol, cetostearyl alcohol]

Generic: 1% (50 g), 2% (25 g)

Kit, Vaginal/Topical:

Canesten Combi 1 Day Internal + External: Cream for vaginal use 10% (5 g) and cream for external use 1% (10 g)

Canesten Combi 1 Day: Vaginal tablet 500 mg (1s) and cream for external use 1% (10 g) [tablet contains lactose; cream contains benzyl alcohol, cetostearyl alcohol]

Canesten Combi 3 Day: Vaginal tablet 200 mg (3s) and cream for external use 1% (10 g) [tablet contains lactose; cream contains benzyl alcohol, cetostearyl alcohol]

Solution, External:

Clotrimaderm Topical: 1% (20 mL) [contains polyethylene glycol 400]

Administration: Pediatric

Topical: Cream, Lotion, Ointment, Solution: For external use only; avoid contact with eyes. Cleanse and thoroughly dry area prior to application. Apply a thin layer and rub gently into affected area; for tinea infections, also apply to surrounding areas (~1 to 2 cm beyond lesion border) (Ref). For tinea pedis (athlete's foot), pay special attention to the spaces between the toes.

Vaginal:

Cream:

Internal use (1%, 2%, or 10% [Canadian product]): Insert full applicator into vagina gently, and slowly expel cream into vagina. Wash applicator with soap and water following use. Do not use tampons, douches, spermicides, or other vaginal products or have vaginal intercourse during treatment.

External use (1%, 2%): Cream may be applied externally for itching and irritation of vaginal and surrounding areas.

Vaginal tablet (Canadian product): Insert deep into the vagina using the applicator to ensure tablet dissolves completely. Administration at bedtime is preferred. If tablet does not dissolve completely within 1 night, consider use of vaginal cream.

Administration: Adult

Intravaginal: For vaginal use only

Cream: Internal use (1%, 2%, or 10% [Canadian product]): Insert deep into the vagina via manufacturer provided applicator. External use (1% or 2%): May be applied externally for itching and irritation of surrounding areas. Do not use tampons, douches, spermicides, or other vaginal products or have vaginal intercourse during treatment.

Vaginal tablet [Canadian product]: Insert deep into the vagina to ensure tablet dissolves completely. If tablet does not dissolve completely within one night, consider use of a vaginal cream.

Topical: For external use only; avoid contact with eyes and application to severely cracked or irritated areas. Cleanse and thoroughly dry area prior to application. Apply a thin layer to affected area. For treatment of athlete's foot, pay special attention to spaces between the toes; wear well-fitting, ventilated shoes and change shoes and socks at least once a day.

Storage/Stability

Recommendations vary by manufacturer. Some products are only recommended to be stored at controlled room temperature and others may be stored under refrigeration or at room temperature; refer to manufacturer's labeling for product-specific storage recommendations.

Use

Topical cream, lotion, and solution: Topical treatment of tinea corporis, tinea cruris, and tinea pedis and relief of associated itching, cracking, burning, and discomfort (OTC product: FDA approved in ages ≥2 years and adults). Note: Topical therapy is not effective for infection of the scalp or nails.

Topical ointment: Topical treatment of cutaneous candida albicans, tinea corporis, and tinea cruris; relief of associated itching, scaling, cracking, burning, redness, soreness and irritation; management of tinea pedis (discomfort, scaly skin between the toes or burning feet) (OTC product: All indications: FDA approved in ages ≥2 years and adults). Note: Topical therapy is not effective for infection of the scalp or nails.

Vaginal cream: Treatment of vulvovaginal candidiasis and relief of associated external itching (FDA approved in ages ≥12 years and adults).

Note: Approved ages and uses for generic products may vary; consult labeling for specific information.

Medication Safety Issues

Sound-alike/look-alike issues:

Clotrimazole may be confused with co-trimoxazole

Lotrimin may be confused with Lotrisone

International issues:

Cloderm: Brand name for clotrimazole [Germany], but also brand name for alclomethasone [Indonesia]; clobetasol [China, India, Malaysia, Singapore, Thailand]; clocortolone [US, Canada]

Canesten: Brand name for clotrimazole [multiple international markets] may be confused with Canesten Bifonazol Comp brand name for bifonazole/urea [Austria]; Canesten Extra brand name for bifonazole [China, Germany]; Canesten Extra Nagelset brand name for bifonazole/urea [Denmark]; Canesten Fluconazole brand name for fluconazole [New Zealand]; Canesten Oasis brand name for sodium citrate [Great Britain]; Canesten Once Daily brand name for bifonazole [Australia]; Canesten Oral brand name for fluconazole [United Kingdom]; Cenestin brand name for estrogens (conjugated A/synthetic) [US, Canada]

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program

Progesterone: Antifungal Agents (Vaginal) may decrease therapeutic effects of Progesterone. Risk X: Avoid

Sirolimus (Conventional): Clotrimazole (Topical) may increase serum concentration of Sirolimus (Conventional). Risk C: Monitor

Tacrolimus (Systemic): Clotrimazole (Topical) may increase serum concentration of Tacrolimus (Systemic). Risk C: Monitor

Reproductive Considerations

Vaginal products may weaken latex condoms and diaphragms (CDC [Workowski 2021]).

Pregnancy Considerations

Clotrimazole is minimally absorbed following topical or vaginal administration.

Based on available data, vaginal use of clotrimazole is not associated with an increased risk of adverse pregnancy outcomes (Czeizel 1999; Czeizel 2004; Daniel 2018; Farr 2021; Papadopoulos 2024; Rotem 2018).

Topical azole therapies with 7-day regimens are recommended in pregnant patients with vulvovaginal candidiasis (CDC [Workowski 2021]). Shorter courses of topical azoles are less effective (Young 2001).

Monitoring Parameters

Hypersensitivity, local irritation.

Mechanism of Action

Binds to phospholipids in the fungal cell membrane altering cell wall permeability resulting in loss of essential intracellular elements

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Topical: Negligible through intact skin; Intravaginal: 3% to 10% of dose is absorbed

Time to peak, serum: Vaginal cream: ~24 hours

Brand Names: International

International Brand Names by Country

For country code abbreviations (show table)

(AE) United Arab Emirates: Candid | Canesten | Canexa | Dermatin | Fungotox | Micoter | Myco | Ovis;
(AR) Argentina: Aflorix | Clotri Q | Clotrimazol df | Clotrimazol Ilab | Clotrimazol raymos | Clotrimazol tetrafarm | Clotrix | Empecid | Empecid gyno | Evacare | Eximius | Fiasole | Fungocop premium | Ginezolex | Ikolan | Klomazole | Livomonil | Lomecan v | Medifungol | Medifungol ginex | Medifungol vl | Micoclin | Micomazol | Micomazol Hlb | Micosep | Micosep nf | Micotrim | Mycanden | Otrix | Panmicol | Sinamida Gyno | Sinfung | Trimazol | Verotrizol;
(AT) Austria: Candibene | Canesten | Clotrimazol genericon pharma | Myko cordes | Pedikurol;
(AU) Australia: Amcal antifungal cream broad spectrum | Amcal fem V 6 day cream | Antifungal clotrimazole | Apo-Clotrimazole | Blooms the chemist anti fungal | Broad spectrum antifungal | Canesten | Canesten clotrimazole thrush treatment 6 day | Chemplus anti fungal | Clofeme | Clonea | Clotreme | Clozole | Cm clot a/fungal | Cm clot thrush | Discount drug stores anti fungal | Femizol | Guardian clotrimazole | Gyne lotremin | Pharmacist clotrimazole | Pharmacy action antifungal | Pharmacy action femcream | Pharmacy care antifungal | Pharmacy care femina v 3 day | Pharmacy Choice Clotrimazole | Pharmacy choice clotrimazole antifungal | Pharmacy health antifungal | Pharmacy health clotrimazole | PHARMACY SELECT CLOTRIMAZOLE | Priceline pharmacy clotrimazole | Tinaderm extra | Topizol | Trust antifungal | Trust fem v 3 day cream | Trust fem v 6 day | Tw antifungal | Tw clot thrush trt;
(BD) Bangladesh: Afun | Aristen | Canesten | Canten | Clarizol | Clodal | Cloderm | Closten | Clotrim | Clotrizole | Clozox | Conasyd | Dermasim | Fungin | Fungizol | Fusten | Kanis | Loderm | Maret | Neosten | Nilfun | Tinatrim | Triderm | Trimazole | Zenesten;
(BE) Belgium: Canestene gyn | Canestene intim;
(BF) Burkina Faso: Camysten | Clotri denk | Clotriderm | Fangid | Imazole v;
(BG) Bulgaria: Canesten | Clotrimazol | Clotrimazol abr;
(BR) Brazil: Abc | Abc clotrimazol | Antimicotico martel | Canesten | Clogen | Clomazen | Clomazol | Clonasten | Clotigen | Clotren | Clotriderm | Clotrigel | Clotrimazol | Clotrimix | Dermazol | Dermobene | Dermotrizol | Fungisten | Gino Trimazen | Gino-canesten | Gino-clotrimix | Kinasten | Lfm clotrimazol | Lomecan | Lomecan v | Miclomazol | Miclonazol | Micotrat | Micotrizol | Neo clotrimazyl | Trimazen;
(CH) Switzerland: Canesten | Corisol | Fungotox | Gyno-Canesten | Undex Clotrimazol;
(CI) Côte d'Ivoire: Clotriderm | Clotrine | Fangid | Fungifen;
(CL) Chile: Arnela | Axasol | Canesten | Cestop | Clotrimazol | Clotrimin | Cotrisan | Creminem | Dermicin | Desfungil | Esafung | Ethonazol | Fungos | Funzal | Konifungil | Laboterol | Novacetol | Nysporil | Telugren;
(CN) China: Gyno canesten | Yu lie shuang;
(CO) Colombia: Alibiogyn | Amicozol | Amikozol | Be slim | Biocotryl | Biofemenine | Bkmezol | Cetezol | Clomazol | Clomogyn | Cloritimicotin | Clortrizol | Clotrifem | Clotrim | Clotrimazo | Clotrimazol | Clotrimazol MK | Clotrizin | Creminem | Cutamycon | Entrenos bx | Epicort | Femicrem | Fenilsone | Fungistem | Fungitrix | Fungyclin | Ginolotrimin | Gyno talseclin | Gynocanesten | Gynocomfort | Gynofil | Gynokit one | Gynosten ultra | Intibon | Lomecan v | Lotrimin | Mediclox v | Medizol | Miclotrim | Miclotrin | Micofix c | Micosan | Moralek | Mycoxyl | Mycoxyl crema vaginal | Neo intimo | Pitox | Pitoxskin | Rocicream | Trimisona | Unigliz;
(CZ) Czech Republic: Candibene | Candimax | Canesten | Canifug | Clotrimazol al | Clotrimazol hbf | Clotrimazolum | Cotylena | Fungizid | Jenamazol;
(DE) Germany: Antifungol | Antimyk neu | Antimykal | Apocanda | Azutrimazol | Benzoderm Myco | Canesten | Canesten gyn | Canifug | Cloderm | Clotri denk | Clotri hemopharm | Clotri opt | Clotrigalen | Clotrikad | Clotrimazol | Clotrimazol 1a pharma | Clotrimazol al | Clotrimazol Aristo | Clotrimazol CT | Clotrimazol Sandoz | Cutistad | Durafungol | Fungizid | Gilt | Gyno-Canesten | Jenamazol | Kadefungin | Lokalicid | Mycofug | Myko cordes | Mykofungin | Mykohaug | Mykomed | Ovis neu | Pedisafe | Sd hermal | Suprazol | Uromykol | Warimazol | Warimazol derm;
(DO) Dominican Republic: Axasol | Candid | Candistat | Canesten | Canesten 3 | Canesten triple accion | Clodizol | Clogen | Clomak | Clomatin | Clomazol | Clomizol | Clotrex | Clotribit | Clotrilac | Clotrimazol | Clotrimazol Calox | Clotrimyl | Clotrixil | Clovagil | Cloxiderm | Cloxil | Clozol | Cremasten | Cutamycon | Derma fung | Euvagin | Feminal V | Fragin | Fungizid | Fungoplex | Ginalin | Gromazol | Gynosan | Imazol | Lomecan v | Micoderm | Ovutrim | Septivag | Vagicid | Vagiclox | Vagiflor | Vagimen | VaginUltra | Warimazol;
(EC) Ecuador: Arnela | Beraltrizol | Candistat | Canesten | Canezol | Clemizol plus | Clomazol | Clomazol 3 | Clotrazil | Clotrimazol | Clotrimazol Kronos | Clotrimazol MK | Clotrimazol nifa | Clotrivid | Clozol | Crema anti hongos | Crema de clotrimazol | Cutamycon | Femicrem | Funzal | Gyne lotrimin | Gyno clotrivid | Gyno-Canesten | Gynocanesten | Kro femikol | Lomecan v | Novacetol | Vagicrem | Vagil C | Vagiral;
(EE) Estonia: Antifungol | Canesten | Canifug cremol | Clotrimazol | Clotrimazolum GSK | Cutistad | Fungizid | Jenamazol;
(EG) Egypt: Candistan | Canemazole | Canesten | Closol | Clotriderm | Cutistad | Dermatin | Locasten | Vagizole;
(ES) Spain: Canesmed | Canespie | Canesten | Clotrimazol Bayrop | Clotrimazol gine canesmed | Fungidermo | Gine canesmed | Gine caneste | Gine canesten | Ictan;
(ET) Ethiopia: Candazole | Candigen | Candigo | Clob | Clotri denk | Clotrilin | Gynest | Mycoril | Vagid;
(FI) Finland: Canesten | Klotricid | Lotremin;
(FR) France: Clotrimazole eg labo conseil | Mycohydralin;
(GB) United Kingdom: Boots antifungal | Candiden | Canesten | Canesten af | Canesten once | Canesten thrush | Canesten thrush combi | Clotrimazole Almus | Clotrimazole cox | Clotrimazole kent | Fungederm | Masnoderm | Medisport ath foot | Mycil gold | Wallis ath foot;
(GR) Greece: Canesten | Factodin;
(HK) Hong Kong: Candazole | Candid | Canesten | Clocreme | Clometen | Clotopic | Clotrikam v | Clozole | Cotren | Cristan | Fungesten | Fungistan | Fungizid | Lotremin | Micoter | Mycatopic | Mycoderm c | Mycoril | Mycozole | Myprozole | Synesten | Tricloderm | Trimazole;
(HR) Croatia: Canesten | Canesten 3 | Plimycol;
(HU) Hungary: Candibene | Canesten | Canifug;
(ID) Indonesia: Bernesten | Canesten | Clonitia | Cotristen | Dermifar | Erphamazol | Fungiderm | Gyne lotremin | Hufaderm | Kanesol | Lotremin | Medisten | Myco | Mycofug | Neo ultrasiline | Trimadan;
(IE) Ireland: Canazole | Canesten;
(IL) Israel: Agisten | Clotrimaderm | Fungicare | Myco;
(IN) India: Abzorb | Albistat BG | Antican | Azoderm | Canazole | Candeol | Candex | Candicul | Candid | Candid gold | Candiskin | Canesten | Canfem | Canison | Canitross | Cansoft | Canstat | Cantop | Cazol | Clean and Dry | Clobrate | Clocidol | Clocip | Cloderm | Clodid | Clodospin | Clomax | Clomed | Closupp | Clotigem | Clotopic | Clotrim V | Clotrin | Clozol | Ctm | Cvate | Czson | Decand | Defungin-p | Fluol | Fungistat | Glocan | Gynostatum | Imidil | Itch | Itchnil | Kansel | Kivzole | Lotril | Moncid | Monpic | Mycoban | Mycocid | Mycoclear | Mycopar C | Nifugal | Nuclovate | Rexizole | Selsyd | Statum | Surfaz | Tinamon | Tolnaderm-bs | Topiclo | Translipo c | Triben | Zocon c | Zycare;
(IQ) Iraq: As fugidin | Clotridain | Fugeden | Fugideen d | Fugidim mdi | Handistan | Klotrimazol awa;
(IT) Italy: Antimicotico same | Canesten | Cangil | Clotrimazolo Doc | Clotrimazolo EG | Clotrimazolo Fg | Clotrimazolo pmg | Gyno canesten;
(JO) Jordan: Candizol | Canesten | Clocim | Clotrim | Clozole | Dermatin | Dermazol | Micoter | Myco;
(JP) Japan: Clostrin | Clostrin ace | Cobart | Crie | Dinin | Elcid | Empecid | Empecid l | Enschent | Enschent taiyo | Enschent towa | Hakuserin | Hogomine new | Kotozole kotobuki | Kotozole nikken | Peckle | Scorpio | Taon | Tapit;
(KE) Kenya: Albican | Candiclo | Candid | Candigo | Candistat | Canesten | Canison | Clob | Clomzole | Clostin | Clotri denk | Clotrine | Clozole | Clozole plus | Dazole | Dermosporin | Fungicip | Fungnil | Gynest | Gynocid | Gynosporin | Gynostatum | Imazole v | Imidil | Kensten | Kremdid | Labesten | Micoderm | Neosten | Unisten | Vagid;
(KR) Korea, Republic of: C-Cream | Camazol | Candico | Candiderm | Canesten | Canezol | Caromasten | Casten | Chromazole | Comadin | Cristan | Elline | Gandan | Hanezol | Lomazol | Myco-hermal | Rimazole | Romazole | Tarimasol | Tarimazole | Trinat;
(KW) Kuwait: Candistan | Canesten | Gromazol | Micoter | Opizole | Warimazol;
(LB) Lebanon: Canesten | Imazole v | Locasten | Micoter | Opizole | Vagid;
(LT) Lithuania: Antifungol | Candibene | Candid | Canesten | Canifug | Clotrimazol | Clotrimazole Ingen Pharma | Clotrimazolum GSK | Clotrimazolum Sanitas | Fungizid | Imidil | Jenamazol | Mykofungin | Ovis;
(LU) Luxembourg: Canestene intim | Fungizid;
(LV) Latvia: Antifungol | Candibene | Candid | Canesten | Canifug | Clob | Clotrimazol | Clotrimazolum | Clotrimazolum GSK | Cutistad | Fungizid | Imidil | Jenamazol | Mykofungin | Ovis;
(MA) Morocco: Canestene | Clomiter | Gyno-Canesten | Mycohydralin;
(MX) Mexico: Altenal | Bemynex v | Bonum | Candimon | Candimon v | Candiphen | Candiphen-v | Canesten | Canesten v | Cerylor | Clocan | Clomacin | Clomacin P | Clotrimazol | Clotrimazol gi | Clotrimazol maver | Clotrimazol qs | Deregel | Dermasten | Euroderm | Liferzol | Liferzol v | Lodirtrem | Lomecan v | Lonestin | Lotrimin | Lozamir c | Lozamir v | Sognohsin | Sognohsin v | Tenescan | Tenescan v | Traxelan | Trimazelon | Venuma;
(MY) Malaysia: Antifungol | Axcel Clotrimazole | Candazole | Candid | Candinil | Canesten | Canesten v | Canezin | Clomaz | Clomazol | Clomazole | Closten | Clotrin | Clozic | Clozole | Comazol | Cotren | Covee | Creobic | Cristan | Loriderm | Lotremin | Micoter | Rangyn | Surfaz | Tinea kare | Trimazol;
(NG) Nigeria: Clavestan | Gynesatum | Imazole v | Itchi c | Mycoten | Reacoten | Vagiheal;
(NL) Netherlands: Canesten | Canesten foot | Canesten gyno | Canesten gyno 1 | Canesten gyno 3 | Canesten skin | Canestene | Clotrimazol | Parvemaxol;
(NO) Norway: Canesten | Fungisten | Klotrimazol | Klotrimazol mylan;
(NZ) New Zealand: Antifungal clotrimazole | Canesten | Clocreme | Clomazol | Clotrihexal | Clotrimaderm | Pharmacy health antifungal;
(PA) Panama: Clotrimax | Clotrimax v;
(PE) Peru: Bonacan | Candid | Canesten | Canestol | Canestol-e | Clotil | Clotrialiv | Clotrimazol | Clotrinesten | Clotry | Clozol | Dequazol t | Dermicol | Esporex | Fungolisin s | Ginacaba | Ginet | Gynocanesten | Hongoderm | Lipfungol | Lomecan v | Lotramina | Micodermasan | Micosan | Micotres forte | Micotrim Vaginal | Micutilin | Neomycol | Notiderm nf | Perfungol | Polik | Statum | Topimazol | Vagtrizol;
(PH) Philippines: Candexin | Candiva | Canesten | Canison | Clogesten | Clotrigen | Clotrimazole Pacific | Dermotrim | Fungistin | Gynesol | Topiclo | Trimacort | Vagizol | Zoleskin;
(PK) Pakistan: Agisten | Altazole | Arnastin cream | Arvizol v | Barresten | Barresten vaginal cream | Benastin | Benestine | Biotrim | Canazole | Candid v | Canesten | Canix | Cara Clot | Catazol v | Cesten | Clim | Clodesone | Clomacef | Clomacef vaginal | Clomazol | Cloteen V | Clotri | Clotrim | Clotrinor | Clozole | Clozox | Ctm | Dermofit | Dermosporin | Dermotrim | Eclo v | Flotizol | Gynosafe | Gynosporin | Lavizole | Lotrigen | Maftrim | Monozole | Novesten | Oligyn | Plimazole | Stiemazol | Trimzol | Tycelex | Vaginex-1 | Vagizole | Warimazol | Wormclo | Ziltasim | Zolotrim;
(PL) Poland: Canesten | Clotidal | Clotrimazol | Clotrimazolum | Clotrimazolum hasco | Fungizid | Gineintima clotriactive | Micoter | Plimycol;
(PR) Puerto Rico: Alevazol | Anti fungal cream | Clotrim antifungal | Clotrimazole 3 | Clotrimazole 7 | Clotrimazole AF | Fungicure Intensiv | Gyne lotrimin | Lotrimin | Lotrimin AF | Mycelex | Mycelex-7 | Mycelex-g | Pro ex antifungal;
(PT) Portugal: Candid | Candigen | Candiset | Canesten | Clotrimazol | Clotrimazol 1% | Clotrimazol basi | Clotrimazol Bluepharma | Clotrimazol farmoz | Clotrimazol Generis | Gino hadazin | Gino-canesten | Gino-lotremine | Hadazin | Holginec | Holpemic | Ligynax | Lotremine | Micolysin | Nalbix | Pan fungex;
(PY) Paraguay: Clidian | Clotrimazol caplin point | Clotrimazol mintlab | Imagine | Micofinal | Micoplus | Micosep | Trimicol | Vagibilac;
(QA) Qatar: Candid | Canditrim | Canesten | Clotrim | Dermatin | Medsten | Opizole | Warimazol Derm;
(RO) Romania: Canesten | Canesten dual action | Clotrimazol | Clotrimazol atb | Clotrimazol fiterman | Clotrimazol hyperion | Clotrimazol rompharm | Clotrimazol slavia | Clotrimazol zentiva;
(RU) Russian Federation: Amyclon | Antifungol | Candibene | Candid | Candizol | Canesten | Canison | Catrisol | Clotrimazol | Clotrimazol akrikhin | Clotrimazole bringer | Clotriran | Factodin | Fungicip | Funginal | Imidil | Jenamazol | Menstan;
(SA) Saudi Arabia: Canesten | Clozole | Dermatin | Fungo | Medsten | Micoter | Opizole;
(SE) Sweden: Canesten | Clotriferm | Klotrimazol mylan;
(SG) Singapore: Axcel Clotrimazole | Candazole | Candid | Canesten | Clozole | Cristan | Fungesten | Lotremin | Myco | Mycoril | Sastid Anti-Fungal;
(SI) Slovenia: Canesten | Canifug;
(SK) Slovakia: Antifungol | Candibene | Candimax | Canesten | Canifug | Clotrimazol | Clotrimazolum | Jenamazol;
(SL) Sierra Leone: Welasten;
(SR) Suriname: Canesten | Clotri denk | Clotrimaderm | Warimazol derm | Warimazol vag;
(TH) Thailand: 246 | Calcrem | Camazole | Canadine | Canazol | Candazole | Candex | Candid | Candinas | Canecin | Canesten | Canesten vc3 | Chingazol | Clomaz | Clomazol | Clothasone | Clotricin | Clotriderm | Clotrimed | Clotrin | Comazol | Cotiderm | Cotren | Defungo | Dermaten | Dermizole | Fadae | Fango | Feminex | Fungiderm | Gynesten | Gynosten | Hofra | Komazone | Locassen | Lyma | Mazole | Myco | Mycoda | Mycoril | Mycotopic | Mycozole | Myda | Mysab | Promazole | Taraten | Vamazole | Vanesten | Zema;
(TN) Tunisia: Camysten;
(TR) Turkey: Canesten | Clozol | Fungosten;
(TW) Taiwan: Candizole | Canesten | Cansen | Cb | Chidamine | Clo t | Clofumale | Clomazin | Clomazole | Clomelon | Clomine | Closten | Clotri denk | Clozole | Comyer | Elcid | Empesuto | Enschent | Fumazole | Fungicide | Kadefungin | Korzin | Mycoril | Mycosten | Nalbix | Powzol | Souriree Clomazen;
(TZ) Tanzania, United Republic of: Fungifen;
(UA) Ukraine: Candibene | Candid | Canesten | Canison | Clofan | Clotrimazol | Factodin | Gyne lotrimin | Jenamazol | Sinium;
(UG) Uganda: Cadzole | Camston | Candid | Candigen | Candistat | Candizol | Canesten | Cani maks | Clob | Clonem | Clonex | Closupp | Clotri denk | Clotrilin | Clotrilin v | Clotrine | Clozox | Dazole | Fungicip | Fungiderm | Fungifen | Fungnil | Fungoal | Gynazole | Labesten | Mycoril | Renesten v | Translipo c | Unisten | Vagid;
(UY) Uruguay: Canesten | Clinadol | Clotrimazol | Micomazol | Micosep;
(VE) Venezuela, Bolivarian Republic of: Amicox | Candid | Candistat | Canesten | Clocim | Clortilen | Clotrex | Clotrimazol | Clotrimazol alfa | Clotrizol | Cortix | Dermotrizol | Fugolin | Fungifen | Ginemazol | Ginolotricomb | Gyno canesten | Gyno clonedac | Gyno trizol | Gyno-Canesten | Imazol | Ipalat | Lecibis | Micoativ | Micozol | Oxysol | Sana;
(VN) Viet Nam: Amfuncid | Candipa | Clovaszol | Fistazol | Hoecandazole | Jetry | Patylcrem | Skandid v2 | Zolomax fort;
(ZA) South Africa: A-por | Adco-clotrimazole | Canalba | Candaspor | Candizole | Canesten | Canex | Canex t | Canex v | Clomaderm | Closcript | Clotrimazole biotech | Covospor | Dynaspor | Fungispor | Gynezol | Gyno-trimaze | Innospore | Medaspor | Micomisan | Micro-clotrimazole | Normospor | Pinaspor V | Trimaze | Vari clotrimazole | Xeraspor;
(ZM) Zambia: Butate | Candazole | Candid | Candimar | Clob | Clonex | Closcript | Clotri denk | Clotrine | Ctm | Fungicide | Fungicip | Fungifen | Gogynax | Imazole v | Opizole | Vagid;
(ZW) Zimbabwe: Adco-clotrimazole | Candid | Canesten | Canesten 1VC | Closcript | Clotriderm | Skan did

Abhinav C, Mahajan VK, Mehta KS, Chauhan PS. Allergic contact dermatitis due to clotrimazole with cross-reaction to miconazole. Indian J Dermatol Venereol Leprol. 2015;81(1):80-82. doi:10.4103/0378-6323.148592 [PubMed 25566914]
Ahlfors CE. Benzyl alcohol, kernicterus, and unbound bilirubin. J Pediatr. 2001;139(2):317-319. [PubMed 11487763]
Alevazol (clotrimazole) [prescribing information]. Powell, OH: Capital Pharmaceuticals LLC; January 2024.
Alevazol (clotrimazole) [prescribing information]. Powell, OH: Capital Pharmaceuticals LLC; June 2016.
American Academy of Pediatrics (AAP). In: Kimberlin DW, Banerjee R, Barnett ED, Lynfield R, Sawyer MH, eds. Red Book: 2024-2027 Report of the Committee on Infectious Diseases. 33rd ed. American Academy of Pediatrics; 2024.
Andrews MD, Burns M. Common tinea infections in children. Am Fam Physician. 2008;77(10):1415-1420. [PubMed 18533375]
Berens P, Eglash A, Malloy M, Steube AM. ABM clinical protocol #26: persistent pain with breastfeeding. Breastfeed Med. 2016;11(2):46-53. doi:10.1089/bfm.2016.29002.pjb [PubMed 26881962]
Canesten (clotrimazole) [product monograph]. Mississauga, Ontario, Canada: Bayer Inc; January 2022.
Centers for Disease Control and Prevention (CDC). Neonatal deaths associated with use of benzyl alcohol—United States. MMWR Morb Mortal Wkly Rep. 1982;31(22):290-291. http://www.cdc.gov/mmwr/preview/mmwrhtml/00001109.htm. [PubMed 6810084]
Chander J, Maini S, Subrahmanyan S, Handa A. Otomycosis--a clinico-mycological study and efficacy of mercurochrome in its treatment. Mycopathologia. 1996;135(1):9–12. doi: 10.1007/bf00436569. [PubMed 9008878]
Clotrimazole cream [prescribing information]. Davie, FL: Mohnark Pharmaceuticals, Inc; January 2024.
Clotrimazole cream [prescribing information]. Hawthorne, NY: Taro Pharmaceuticals U.S.A. Inc; October 2015.
Clotrimazole cream [prescribing information]. Livonia, MI: Rugby Laboratories; January 2020.
Clotrimazole topical solution [prescribing information]. Tampa, FL: TruPharma; April 2019.
Clotrimazole 3 day vaginal cream [prescribing information]. Deerfield, IL: Walgreens; received 2025.
Clotrimazole 3 day vaginal cream [prescribing information]. Hawthorne, NY: Taro Pharmaceuticals U.S.A. Inc; October 2016.
Clotrimazole 7 day vaginal cream [prescribing information]. Hawthorne, NY: Taro Pharmaceuticals U.S.A. Inc; July 2012.
Clotrimazole vaginal cream [prescribing information]. Memphis, TN: Strategic Sourcing Services LLC; August 2022.
Clotrimazole vaginal cream [prescribing information]. Novi, MI: CDMA, Inc; October 2024.
Czeizel AE, Fladung B, Vargha P. Preterm birth reduction after clotrimazole treatment during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2004;116(2):157-163. doi:10.1016/j.ejogrb.2004.02.011 [PubMed 15358456]
Czeizel AE, Tóth M, Rockenbauer M. No teratogenic effect after clotrimazole therapy during pregnancy. Epidemiology. 1999;10(4):437-440. doi:10.1097/00001648-199907000-00013 [PubMed 10401880]
Daniel S, Rotem R, Koren G, Lunenfeld E, Levy A. Vaginal antimycotics and the risk for spontaneous abortions. Am J Obstet Gynecol. 2018;218(6):601.e1-601.e7. doi:10.1016/j.ajog.2018.02.013 [PubMed 29510088]
Dehghan M, Akbari N, Alborzi N, Sadani S, Keshtkar AA. Single-dose oral fluconazole versus topical clotrimazole in patients with pityriasis versicolor: a double-blind randomized controlled trial. J Dermatol. 2010;37(8):699-702. doi:10.1111/j.1346-8138.2010.00908.x [PubMed 20649710]
de la Paz Cota BR, Cepero Vega PP, Matus Navarrete JJ, et al. Efficacy and safety of eberconazole 1% otic solution compared to clotrimazole 1% solution in patients with otomycosis. Am J Otolaryngol. 2018;39(3):307-312. doi: 10.1016/j.amjoto.2018.03.017. [PubMed 29551350]
Durdu M, Ilkit M, Tamadon Y, Tolooe A, Rafati H, Seyedmousavi S. Topical and systemic antifungals in dermatology practice. Expert Rev Clin Pharmacol. 2017;10(2):225-237. doi:10.1080/17512433.2017.1263564 [PubMed 27868472]
Farr A, Effendy I, Frey Tirri B, et al. Guideline: vulvovaginal candidosis (AWMF 015/072, level S2k). Mycoses. 2021;64(6):583-602. doi:10.1111/myc.13248 [PubMed 33529414]
Goguen LA. External otitis: treatment. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed December 2, 2019.
Goldstein AO, Goldstein BG. Dermatophyte (tinea) infections. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed August 24, 2021.
Gupta AK, Cooper EA. Update in antifungal therapy of dermatophytosis. Mycopathologia. 2008;166(5-6):353-367. doi:10.1007/s11046-008-9109-0 [PubMed 18478357]
Gupta AK, MacLeod MA, Foley KA, Gupta G, Friedlander SF. Fungal skin infections. Pediatr Rev. 2017;38(1):8-22. doi:10.1542/pir.2015-0140 [PubMed 28044030]
Hill RC, Caplan AS, Elewski B, et al. Expert panel review of skin and hair dermatophytoses in an era of antifungal resistance. Am J Clin Dermatol. 2024;25(3):359-389. doi:10.1007/s40257-024-00848-1 [PubMed 38494575]
"Inactive" ingredients in pharmaceutical products: update (subject review). American Academy of Pediatrics (AAP) Committee on Drugs. Pediatrics. 1997;99(2):268-278. [PubMed 9024461]
Kamalam A, Thambiah AS. Clotrimazole and econazole in dermatophytoses (double blind study). Mykosen. 1980;23(12):707-710. doi:10.1111/j.1439-0507.1980.tb01778.x [PubMed 7012613]
Keczkes K, Leighton I, Good CS. Topical treatment of dermatophytoses and candidoses. Practitioner. 1975;214(1281):412-417. [PubMed 1096122]
Khan F, Muhammad R, Khan MR, et al. Efficacy of topical clotrimazole in treatment of otomycosis. J Ayub Med Coll Abbottabad. 2013;25(1-2):78–80. [PubMed 25098061]
Papadopoulos EA, Howley MM, Fisher SC, et al; National Birth Defects Prevention Study. Antifungal medication use during early pregnancy and the risk of congenital heart defects in the National Birth Defects Prevention Study, 1997-2011. Birth Defects Res. 2024;116(2):e2308. doi:10.1002/bdr2.2308 [PubMed 38343154]
Pappas PG, Kauffman CA, Andes DR, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62(4):e1-e50. doi:10.1093/cid/civ933 [PubMed 26679628]
Paulose KO, Al Khalifa S, Shenoy P, Sharma RK. Mycotic infection of the ear (otomycosis): a prospective study. J Laryngol Otol. 1989;103(1):30–35. doi: 10.1017/s0022215100107960. [PubMed 2921549]
Refer to the manufacturer's labeling.
Roller JA. Contact allergy to clotrimazole. Br Med J. 1978;2(6139):737. doi:10.1136/bmj.2.6139.737 [PubMed 151578]
Rotem R, Fishman B, Daniel S, Koren G, Lunenfeld E, Levy A. Risk of major congenital malformations following first-trimester exposure to vaginal azoles used for treating vulvovaginal candidiasis: a population-based retrospective cohort study. BJOG. 2018;125(12):1550-1556. doi:10.1111/1471-0528.15293 [PubMed 29790255]
US Department of Health and Human Services (HHS) Panel on Opportunistic Infections in Adults and Adolescents with HIV. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/whats-new. Updated September 16, 2024. Accessed October 28, 2024.
van Schalkwyk J, Yudin MH; Infectious Disease Committee. Vulvovaginitis: screening for and management of trichomoniasis, vulvovaginal candidiasis, and bacterial vaginosis. J Obstet Gynaecol Can. 2015;37(3):266-274. doi:10.1016/S1701-2163(15)30316-9 [PubMed 26001874]
van Zuuren EJ, Fedorowicz Z, El-Gohary M. Evidence-based topical treatments for tinea cruris and tinea corporis: a summary of a Cochrane systematic review. Br J Dermatol. 2015;172(3):616-641. doi:10.1111/bjd.13441 [PubMed 25294700]
Votriza-AL (clotrimazole) [prescribing information]. Glendale, CA: Singular Dreamer; received December 2023.
Weinstein A, Berman B. Topical treatment of common superficial tinea infections. Am Fam Physician. 2002;65(10):2095-2102. [PubMed 12046779]
Workowski KA, Bachmann LH, Chan PA, et al; Centers for Disease Control and Prevention (CDC). Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021;70(4):1-187. doi:10.15585/mmwr.rr7004a1 [PubMed 34292926]
Workowski KA, Bolan GA; Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2015 [published correction appears in MMWR Recomm Rep. 2015;64(33):924]. MMWR Recomm Rep. 2015;64(RR-03):1-137. [PubMed 26042815]
Young GL, Jewell D. Topical treatment for vaginal candidiasis (thrush) in pregnancy. Cochrane Database Syst Rev. 2001;(4):CD000225. doi:10.1002/14651858.CD000225 [PubMed 11687074]

Topic 15956 Version 386.0

خرید پکیج

Clotrimazole (topical): Pediatric drug information