Gentamicin (topical): Pediatric drug information

For additional information see "Gentamicin (topical): Drug information" and "Gentamicin (topical): Patient drug information"

For abbreviations, symbols, and age group definitions show table

Therapeutic Category

Antibiotic, Aminoglycoside;
Antibiotic, Topical

Dosing: Pediatric

Dermatologic infection

Dermatologic infection: Infants, Children, and Adolescents: Topical: Cream, Ointment: Apply 3 to 4 times/day to affected area (Ref).

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Liver Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Adult

(For additional information see "Gentamicin (topical): Drug information")

Dermatologic infection

Dermatologic infection: Topical: Apply 3 to 4 times daily to affected area.

Peritoneal dialysis catheter exit-site or tunnel infection, prophylaxis

Peritoneal dialysis catheter exit-site or tunnel infection, prophylaxis (off-label use): Topical: Apply once daily to catheter exit site to prevent infection (Ref). Note: Minimize contact between catheter and gentamicin to reduce risk of catheter damage (Ref).

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Liver Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Adverse Reactions

The following adverse drug reactions are derived from product labeling unless otherwise specified.

Postmarketing: Dermatologic: Erythema of skin, pruritus

Contraindications

Hypersensitivity to gentamicin or any component of the formulation

Warnings/Precautions

Concerns related to adverse effects:

• Superinfection: Prolonged use may result in fungal or bacterial superinfection; discontinue if superinfection is noted.

• Sensitization: Topical use has been associated with local sensitization (redness, irritation); discontinue if sensitization is noted.

Other warnings/precautions:

• Long-term use: Not intended for long-term therapy.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Cream, External:

Generic: 0.1% (15 g, 30 g)

Ointment, External:

Generic: 0.1% (15 g, 30 g)

Generic Equivalent Available: US

Yes

Pricing: US

Cream (Gentamicin Sulfate External)

0.1% (per gram): $3.29

Ointment (Gentamicin Sulfate External)

0.1% (per gram): $3.29

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Pediatric

For external topical use only; not for ophthalmic use. Apply a small amount gently to the cleansed affected area; may cover with gauze dressing.

Administration: Adult

Topical: For external use only; not for ophthalmic use. Apply gently to affected area; may cover with gauze dressing. Remove crust of impetigo contagiosa prior to application. When used to prevent peritoneal dialysis catheter exit-site or tunnel infection, minimize contact with gentamicin and catheter to reduce risk of catheter damage (Ref).

Storage/Stability

Store at 15°C to 30°C (59°F to 86°F).

Use

Topical treatment of superficial infections of the skin including folliculitis, impetigo contagiosa, furunculosis, sycosis barbae, ecthyma, pyoderma gangrenosum, infectious eczematoid dermatitis, pustular acne, pustular psoriasis, infected seborrheic dermatitis or contact dermatitis, infected excoriations and bacterial super-infections of fungal or viral infections (FDA approved for ages >1 year and adults)

Medication Safety Issues

Sound-alike/look-alike issues:

Gentamicin may be confused with gentian violet, kanamycin, vancomycin

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program

There are no known significant interactions.

Mechanism of Action

Interferes with bacterial protein synthesis by binding to 30S ribosomal subunit resulting in a defective bacterial cell membrane

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Systemic absorption is reported following topical application to burn patients (Sawchuk 1980).

Brand Names: International

International Brand Names by Country

For country code abbreviations (show table)

(AE) United Arab Emirates: Cidomycin | Garamycin | Gental | Genticin;
(AR) Argentina: Gentaderm | Gentamicin | Gentamicina fabra | Gentamina | Gentaren | Gentum | Metadyne | Plurisemina | Rupegen | Ultradermis;
(AT) Austria: Refobacin;
(BD) Bangladesh: Genacyn | Genticin | Gentin | Gentosep | Monamycin;
(BE) Belgium: Geomycine;
(BG) Bulgaria: Gentamicin medphano | Gentamycin;
(BR) Brazil: Garacin | Garamicina | Gentamicina | Gentamil;
(CH) Switzerland: Garamycin;
(CL) Chile: Gentalyn | Gentamicina | Gevracilina;
(CO) Colombia: Garamicina | Gentacrem | Gentamas | Gentamicina | Micigent;
(DE) Germany: Gentamycin | Infectogenta | Refobacin | Sulmycin;
(DO) Dominican Republic: Garamicin | Garamicina | Gen forte | Gentaderm | Gentamicina | Gentax;
(EC) Ecuador: Garamicina | Gentaderm | Gentamax | Gentamicina | Sulfato de gentamicina;
(EE) Estonia: Garamycin | Gentamycin;
(EG) Egypt: Apigent | Biogentacin | Cidomycin | Farcocin | Garamycin | Genmycin | Gentaderm | Gentamicin | Gloriagent | Nerhamicin | Refobacin;
(ES) Spain: Gentamival | Gevramycin;
(FI) Finland: Garamycin;
(FR) France: Gentalline;
(GB) United Kingdom: Cidomycin | Genticin;
(GR) Greece: Diakarmon | Genta;
(HK) Hong Kong: Garamycin | Gentacin | Gentamicin | Gentamycin | Gentopic;
(HU) Hungary: Gentamycin;
(ID) Indonesia: Balticin | Bioderm | Dermabiotik | Dermagen | Garabiotic | Garamycin | Garapon | Gentalex | Gentamerck | Gentamicin | Gentamycin | Genticid | Gentiderm | Gragenta | Ikagen | Konigen | Licogenta | Nichogencin | Ottogenta | Paranten | Pyogenta | Rogencin | Sagestam | Salticin;
(IE) Ireland: Cidomycin | Genticin;
(IL) Israel: Garamycin | Gentatrim;
(IN) India: Dermycin | Gentamycin | Gentamycin sulphate | Gentlee | L-genta | Laramycin | Lyramycin | Merigenta | Supragent;
(IQ) Iraq: As ginoden | Genidin;
(IT) Italy: Ciclozinil | Eutopic | Genbrix | Gentacream | Gentalyn | Gentamicina | Gentamicina Almus | Gentamicina alter | Gentamicina doc | Gentamicina eg | Gentamicina idi farmaceutici | Gentamicina ratiopharm | Nemalin | Tacigen;
(JP) Japan: Gentacin;
(KE) Kenya: Gentosep;
(KR) Korea, Republic of: Ahn gook gentamicin sulfate | Gentacin | Gentamicin | Shinpoong Gentamicin | Zentacin;
(KW) Kuwait: Cidomycin | Garamycin;
(LB) Lebanon: Cidomycin | Garamycin;
(LT) Lithuania: Gentamycin;
(LU) Luxembourg: Geomycine;
(LV) Latvia: Gentamycin;
(MA) Morocco: Gentalline;
(MX) Mexico: Garamicina;
(MY) Malaysia: Beagenta | Dermogen | Garamycin | Gentacin | Gentamicin | Gentamycin | Lisarin | Miramycin;
(NG) Nigeria: Rgi gentamicin cream;
(NL) Netherlands: Garamycin;
(NO) Norway: Infectogenta | Refobacin;
(PE) Peru: Gentalyn | Gentamicina;
(PH) Philippines: Garamycin;
(PK) Pakistan: Atcogen | Cingenta | G-mycin | Gentalek | Gentamicin | Gentamycin | Genticyn | Gentriderm | Karmagen | Mafgent | Swigen | Valigent;
(PL) Poland: Gentamycin;
(PR) Puerto Rico: Garamycin;
(PT) Portugal: Garalone | Gentamicina | Gentocil;
(PY) Paraguay: Cremoterapico biotic | Gental g | Gentaland biotic | Gentamina;
(QA) Qatar: Biogentacin | Farcocin | Garamycin | Genta | Gental | Gentapar | Gevramycin | Refobacin | Septopal Chain;
(RO) Romania: Gentatrim;
(RU) Russian Federation: Garamycin;
(SA) Saudi Arabia: Cidomycin | Garamycin;
(SG) Singapore: Dermogen | Garamycin | Gentamicin | Gentamycin | Gentopic | Miramycin;
(TH) Thailand: Faracin | Garamycin | Gencidal | Gencin | Genda | Genmocin | Gentacin | Gentaderm | Gental | Gentamycin | Gentramycin | Gentrex | Grammicin | Grammixin | Miramycin | Pharacin | Skinfect | Versigen;
(TR) Turkey: Garamycin | Gentaderm | Gentamycin;
(TW) Taiwan: Gamicin | Garamycin | Gencin | Genrite | Genta | Gentacin | Gentamicin | Gentamycin | Gentatrim | Gentermay;
(UA) Ukraine: Gentamycin;
(UG) Uganda: Farcocin;
(UY) Uruguay: Gentamina;
(VE) Venezuela, Bolivarian Republic of: Catogen | Gentamicina | Gentisul;
(ZA) South Africa: Garamycin;
(ZM) Zambia: Gentamicin

Bernardini J, Bender F, Florio T, et al. Randomized, double-blind trial of antibiotic exit site cream for prevention of exit site infection in peritoneal dialysis patients. J Am Soc Nephrol. 2005;16(2):539-545. doi:10.1681/ASN.2004090773 [PubMed 15625071]
Bradley JS, Nelson JD, Barnett E, et al. Nelson's Pediatric Antimicrobial Therapy. 23rd ed. American Academy of Pediatrics; 2017.
Chow KM, Li PK, Cho Y, et al. ISPD catheter-related infection recommendations: 2023 update. Perit Dial Int. 2023;43(3):201-219. doi:10.1177/08968608231172740 [PubMed 37232412]
Chu KH, Choy WY, Cheung CC, et al. A prospective study of the efficacy of local application of gentamicin versus mupirocin in the prevention of peritoneal dialysis catheter-related infections. Perit Dial Int. 2008;28(5):505-508. [PubMed 18708544]
Gardezi AI, Schlageter KW, Foster DM, Astor BC, Chan MR, Waheed S. Erosion of the silicone peritoneal dialysis catheter with the use of gentamicin cream at the exit site. Adv Perit Dial. 2016;32:15-18. [PubMed 28988584]
Gentamicin ointment [prescribing information]. Buena, NJ: Teligent Pharma Inc; April 2018.
Gentamicin sulfate cream [prescribing information]. Buena, NJ: Teligent Pharma Inc; September 2021.
Mahaldar A, Weisz M, Kathuria P. Comparison of gentamicin and mupirocin in the prevention of exit-site infection and peritonitis in peritoneal dialysis. Adv Perit Dial. 2009;25:56-59. [PubMed 19886318]
Sawchuk RJ, Rector TS. Drug kinetics in burn patients. Clin Pharmacokinet. 1980;5(6):548-556.

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Gentamicin (topical): Pediatric drug information