Version May 2024
Radionuclide cisternography: Intrathecal (based on 70 kg patient): 0.5 mCi (18.5 MBq)
There are no dosage adjustments provided in the manufacturer’s labeling. Use caution with severe impairment.
There are no dosage adjustments provided in the manufacturer’s labeling.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.
Central nervous system: Aseptic meningitis, meningitis
Dermatologic: Dermatological reaction
Gastrointestinal: Vomiting
Miscellaneous: Fever
There are no contraindications listed in the manufacturer’s labeling.
Disease-related concerns:
• Renal impairment: Use with caution in patients with severe renal impairment.
Special handling:
• Radiopharmaceutical: Use appropriate precautions for handling, disposal, and minimizing exposure to patients and healthcare personnel. Use under supervision of individuals with experience/training in the handling of radioactive materials approved by the applicable regulatory authority.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Intrathecal:
Generic: (1 ea)
Yes
For intrathecal administration. Radiopharmaceutical; use appropriate precautions for handling and disposal.
Radionuclide cisternography: For use in radionuclide cisternography
The Institute for Safe Medication Practices (ISMP) includes this medication (intrathecal administration) among its list of drugs that have a heightened risk of causing significant patient harm when used in error.
Radiopharmaceutical: Use appropriate precaution for handling, disposal, and minimizing exposure to patients and healthcare personnel. Use under supervision of experienced personnel. Should be stored in original lead container or adequate radiation shield.
Animal studies have not been conducted. Radiopharmaceuticals have the potential to cause fetal harm. Use during pregnancy only if clearly needed.
In one patient report, only 0.2% of the administered dose was excreted in breast milk, which would have resulted in an infant dose of less than 1 mrem (0.01 mSv) if breast-feeding had not been interrupted. This amount is so low that interruption of breast-feeding is not necessary (Johnson 1995).
Half-life: Physical: 67.9 hours
Excretion: Urine (~65% after 24 hours)
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