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Five-factor score in eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

Five-factor score in eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
1996 five-factor score[1] Revised 2011 five-factor score[2]
Cardiac involvement Age >65 years
Gastrointestinal disease (bleeding, perforation, infarction, or pancreatitis) Cardiac insufficiency
Renal insufficiency (plasma creatinine concentration >1.6 mg/dL [141 mmol/L]) Renal insufficiency (stabilized peak creatinine 1.7 mg/dL [150 micromol/L])
Proteinuria (>1 g/day) Gastrointestinal involvement
Central nervous system involvement Absence of ENT manifestations (presence is associated with a better prognosis)
The presence of each factor is given one point. The FFS score ranges from 0 to 2: a score of 0 is given when none of the factors is present, a score of 1 for one factor, and a score of 2 for two or more factors.
FFS: five-factor score; ENT: ear, nose, and throat.
Data from:
  1. Guillevin L, Lhote F, Gayraud M, et al. Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients. Medicine 1996; 75:17.
  2. Guillevin L, Pagnoux C, Seror R, et al. The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort. Medicine (Baltimore) 2011; 90:19.
Graphic 50118 Version 5.0

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