Solutions for standardized desensitization protocol (using an example of a target drug dose of 1000 mg)

Solution	Volume in mL	Concentration	Dose (mg) in solution
1	250 mL	0.04 mg/mL	10 mg
2	250 mL	0.4 mg/mL	100 mg
3	250 mL	4 mg/mL	1000 mg

The above three solutions are required for the standardized protocol for drug desensitizations for immediate hypersensitivity reactions. Solution 3 is the normal intravenous preparation of the drug as it is usually administered (ie, 1000 mg in 250 mL). Solution 2 is a 10-fold dilution of solution 3, and solution 1 is a 10-fold dilution of solution 2. Note that if the full amount of all three solutions were administered, a total of 1110 mg would be given. To avoid this, only part of solution 3 is infused.

Courtesy of Mariana Castells, MD, PhD.

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Solutions for standardized desensitization protocol (using an example of a target drug dose of 1000 mg)