Distinguishing characteristics of type I versus type II heparin-induced thrombocytopenia

	Type I	Type II
Frequency	10 to 20%	1 to 3%
Timing of onset	1 to 4 days	5 to 10 days after start of heparin
Nadir platelet count	100,000/microL	usually >20,000/microL; median nadir 60,000/microL
Antibody mediated	No	Yes
Thromboembolic sequelae	None	30 to 80%
Hemorrhagic sequelae	None	Rare
Management	Observe	Cessation of heparin, alternative nonheparin anticoagulation to prevent thrombosis

Adapted from: Brieger DB, Mak KH, Kottke-Marchant K, Topol EJ. Heparin-induced thrombocytopenia. J Am Coll Cardiol 1998; 31:1449.

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