| Sick infant |
| Neonatal history |
| Is there a history of perinatal asphyxia? |
| Does the child have meconium aspiration syndrome or respiratory distress syndrome? |
| Is there evidence of infection? |
| Necrotizing enterocolitis |
| Sepsis/DIC |
| Does the child look abnormal? |
| Toxoplasmosis, rubella, cytomegalovirus, herpes simplex |
| Chromosome abnormality |
| Is the child small for gestational age? |
| Could the child have a thrombus? Were there indwelling catheters? |
| Did the child have an intracranial hemorrhage? |
| Maternal history |
| Prenatal or perinatal infection |
| Preeclampsia, hemolytic anemia, elevated liver enzymes, low platelet count |
| Abnormal placenta |
| Neonatal examination |
| Head circumference, weight percentile |
| Congenital anomalies: radial rays, thumbs, dysmorphic features |
| Hepatosplenomegaly |
| Blueberry muffin rash |
| Hemangioma |
| Neonatal laboratory values |
| Abnormalities in the white blood cell count or hematocrit |
| Hyperbilirubinemia or liver function test abnormalitites |
| Evidence of coagulopathy or DIC |
