Testosterone and DHT in 5-alpha-reductase 2 deficiency

The effects of hCG and T administration on serum T and DHT concentrations and their ratio in subjects with steroid 5-alpha-reductase 2 deficiency. Serum hormones were measured in the basal state, 96 hours after the administration of hCG, and 48 hours after the administration of mixed testosterone esters. Patient values are the circles, the light gray areas represent the results (±1 SD) in 8 controls, and the dark gray areas the results in 7 hypogonadal males on T replacement. Serum DHT is lower and the T/DHT ratio higher in the patients with 5-alpha-reductase 2 deficiency.