Version June 2024
| Feature | Phototoxicity | Photoallergy |
| Incidence | High | Low |
| Amount of agent required for photosensitivity | Large | Small |
| Onset after exposure to photosensitizer and light | Minutes to hours | 24 hours or more |
| Requirement for immunization | No | Yes |
| Clinical characteristics | Exaggerated sunburn | Acute, subacute, or chronic dermatitis |
| Distribution | Exposed skin only | Exposed skin; may spread to unexposed skin |
| Pigmentary changes | Frequent | Unusual |
| Histopathologic features | Epidermal cell degeneration; dermal edema and vasodilatation; sparse mononuclear infiltrate | Epidermal spongiosis; exocytosis of mononuclear cells; dermal mononuclear cell infiltrate |
| Development of persistent light reaction | No | Yes |
| Cross-reactions to related agents | No | Yes |
| Covalent binding with carrier protein | No | Yes |
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