Benefit of recombinant TPO to murine transplant donors
Benefit of recombinant TPO to murine transplant donors
Mice were treated with lethal irradiation followed by the transplantation of 1 x 105 bone marrow cells and the recovery of the blood counts followed. Top panel: The administration of various doses of saline or thrombopoietin (TPO) after transplantation had no effect on platelet recovery. Bottom panel: Accelerated platelet recovery occurred when mice were transplanted with bone marrow from TPO-treated donors; the response was similar in recipients treated after transplantation with saline or TPO. Recipients of marrow from TPO-treated donors also had accelerated recovery of the red cell counts (not shown).
Data from: Fibbe WE, Heemskerk DP, Laterveer L, et al. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood 1995; 86:3308.
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