Frequency of oral clefts in relatives based on the proband's phenotype

Relative	CL (percent)	CL/P (percent)	CP (percent)
Sibling	2.5	3.9	3.3
Half sibling	1.0	0.5	1.0
Parent	2.5	2.5	2.1
Offspring	3.5	4.1	4.2
Niece/nephew	0.9	0.8	1.1
Aunt/uncle	0.6	1.1	0.6
First cousin	0.3	0.5	0.4

Recurrence_risk_clefts.htm

CL: cleft lip; CL/P: cleft lip with or without cleft palate; CP: cleft palate.

Data from: Grosen D, Chavrier C, Skytthe A, et al. A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance. J Med Genet 2009.

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