Frequency of oral clefts in relatives based on the proband's phenotype
Frequency of oral clefts in relatives based on the proband's phenotype
Relative
CL (percent)
CL/P (percent)
CP (percent)
Sibling
2.2
4.6
3.3
Half sibling
0.8
0.7
1.3
Parent
2.5
2.5
2.1
Offspring
3.5
4.1
4.2
Niece/nephew
0.9
0.8
1.1
Aunt/uncle
0.6
1.1
0.6
First cousin
0.3
0.5
0.4
CL: cleft lip; CL/P: cleft lip with or without cleft palate; CP: cleft palate.
Data from: Grosen D, Chavrier C, Skytthe A, et al. A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance. J Med Genet 2010;47:162.