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Alternate forms of nicotine

Alternate forms of nicotine
  Alternate names Description Comments
Smoked tobacco
Cigar Cigarillo, figurado   Depending on size, nicotine content may be up to 4 times that of a cigarette.
Hookah Pipes, waterpipe, hubble bubble, narghile, shisha Lit tobacco bubbles through water and inhaled through a shared mouthpiece. Use of black "air-cured" tobacco has higher risk of esophageal cancer. The filtering effect of water does not make it less dangerous.
Bidi   Hand-rolled, leaf-wrapped cigarette, often with sweet flavors such as chocolate or cherry. Nicotine content is 3 to 5 times that of a cigarette.
Kretek Clove cigarette Rolled mixture of tobacco, cloves, and other additives.  
Noncombustible forms of nicotine
Electronic nicotine delivery devices (ENDS; including e-cigarettes) E-cigarette, vapor cigarette, personal vaporizer, vape pipe/pen/stick, hookah pen, e-hookah, mod, pod-mod, tank system, Juul (and other brand names) Battery-powered device that provides doses of nicotine for inhalation. A nicotine-containing liquid is put into the device in a cartridge or in drops. Available in a variety of flavors.

E-cigarettes and other ENDS devices are widely available from internet sources. These forms of nicotine are not harmless. Nicotine exposure during adolescence can cause addiction and harm the developing brain[1]. Patients may not report that they "smoke" if they use ENDS devices or are "juuling," so specific screening questions should be used. E-cigarettes are often used to vaporize cannabis or other substances.

Refer to UpToDate content on e-cigarettes.
Nontobacco oral nicotine products Synthetic or "tobacco-free" oral nicotine; because these are not approved as cessation aids, they are sometimes known as "nontherapeutic" nicotine products Available as gum, lozenges, gummies, and pouches, in appealing flavors (fruits and sweets). Relatively new form of nicotine product. Aspects that may particularly appeal to youth include availability in appealing flavors, forms that are easily concealed, and marketing messages that suggest minimal harm[2].
Tobacco-derived oral nicotine   Contains nicotine derived from tobacco but not unrefined tobacco. The FDA has authorized the marketing of some of these products, with the rationale that they are less harmful than other forms of smokeless tobacco.
Heat-not-burn (HNB) tobacco products HNB tobacco Electric blade heats tobacco stick to much lower temperature compared with a tobacco cigarette. Nicotine content is approximately 85% that of a traditional tobacco cigarette. In addition, HNB products contain lower amounts of some other harmful constituents compared with the smoke of a traditional cigarette[3].
Chewing tobacco Chew, spit tobacco Shredded tobacco leaves, often sweetened, and available as loose leaf, "plug," or "twist." It is used by holding it in the mouth between the gum and cheek. Chewing tobacco is associated with substantial risks for gum disease, mouth cancer, and oral sores; it also causes stained teeth, bad breath, and loss of taste.
Snuff Pinch, dip Finely ground tobacco, either dry or moist. Dry snuff is usually inhaled through the nostrils; moist snuff is usually held in the mouth for absorption, similar to chewing tobacco. Similar to chewing tobacco above.
Snus   A form of moist snuff, dispensed in packets or sachets. These are held in the mouth for absorption, similar to chewing tobacco, but designed so that spitting is not required. Nicotine content is 2 to 6 times that of a cigarette.
Dissolvable tobacco   Dissolvable tobacco strips, sticks, or orbs (pellets similar to Tic Tac candies). Delivers between 0.5 and 2 times the nicotine of a cigarette. Allows for covert use of tobacco; risk of inadvertent toxic ingestion by young children. High content of un-ionized nicotine leads to rapid absorption and potentially increases nicotine toxicity.
ENDs: electronic nicotine delivery devices; e-cigarette: electronic cigarette; FDA: US Food and Drug Administration; HNB: heat-not-burn.
References:
  1. E-cigarette use among youth and young adults: A report of the Surgeon General (2016). Available at: https://e-cigarettes.surgeongeneral.gov/documents/2016_SGR_Exec_Summ_508.pdf.
  2. Harlow AF, Vogel EA, Tackett AP, et al. Adolescent Use of Flavored Non-Tobacco Oral Nicotine Products. Pediatrics 2022; 150.
  3. Auer R, Concha-Lozano N, Jacot-Sadowski I, et al. Heat-Not-Burn Tobacco Cigarettes: Smoke by Any Other Name. JAMA Intern Med 2017; 177:1050.
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