Effect of estrogen dose on change in bone mineral density (BMD) in postmenopausal women

Mean percentage of change from baseline in lumbar spine (L1-4) BMD measured by DXA. Placebo (diamonds), esterified estrogens: 0.3 mg (squares), 0.625 mg (triangles), 1.25 mg (circles). BMD changes at all timepoints and at all esterified estrogen doses were significantly different from those occurring with placebo use.