Version May 2024
| Organ system | Late effect of chemotherapy (agents) | Late effect of radiotherapy |
| Bone and soft tissues | Avascular necrosis (corticosteroids) | Short stature Atrophy Fibrosis Osteonecrosis Second cancers |
| Cardiovascular | Cardiomyopathy (anthracyclines, trastuzumab) | Pericardial effusion Pericarditis Coronary artery and peripheral vascular disease |
| Pulmonary | Pulmonary fibrosis Interstitial pneumonitis (bleomycin) | Pulmonary fibrosis Decreased lung volumes |
| Central nervous system | Leukoencephalopathy (methotrexate) | Neurocognitive impairment Radiation necrosis Second malignancies |
| Peripheral nervous system | Peripheral neuropathy Hearing loss (cisplatin, taxanes, vinca alkaloids) | Brachial plexopathy Lumbosacral plexopathy |
| Hematological | Myelodyplastic syndromes and secondary leukemias (alkylating agents) | Myelodysplasia |
| Renal | Decreased creatinine clearance (cisplatin, methotrexate) | Decreased creatinine clearance Hypertension |
| Genitourinary | Bladder fibrosis Hemorrhagic cystitis Bladder cancer (cyclophosphamide) | Bladder fibrosis Contractures |
| Gastrointestinal | Abnormal liver function tests Hepatic fibrosis Cirrhosis (methotrexate) | Malabsorption Stricture Radiation proctitis Second cancers |
| Pituitary | – | Growth hormone deficiency Pituitary deficiency Metabolic syndrome Obesity Diabetes |
| Thyroid | Hypothyroidism (sunitinib) | Hyperthyroidism Hypothyroidism Thyroid nodules Thyroid cancer |
| Gonadal | Men | |
| Sterility (alkylating agents) | Sterility Leydig cell dysfunction | |
| Women | ||
| Sterility Premature menopause (alkylating agents) | Ovarian failure Early menopause | |
| Opthalmologic | Cataracts (steroids) | Cataracts Retinopathy |
| Skin | - | Second cancers |
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