Incidence of prolonged chemotherapy-induced amenorrhea according to age and type of adjuvant chemotherapy regimen

Regimen	Incidence chemotherapy-induced amenorrhea according to age at treatment initiation (%)
Regimen	<40 years	≥40 years
CMF	30 to 80	60 to 96
AC	13 to 30	57 to 63
FEC/FAC	10 to 25	80 to 90
AC followed by a single agent taxane	15 to 42	66 to 77

CMF: cyclophosphamide, methotrexate plus fluorouracil; AC: doxorubicin plus cyclophosphamide; FEC: fluorouracil, epirubicin plus cyclophosphamide; FAC: fluorouracil, doxorubicin plus cyclophosphamide.

Data from: Stearns V, Schneider B, Henry NL, et al. Breast cancer treatment and ovarian failure: risk factors and emerging genetic determinants. Nat Rev Cancer 2006; 6:886.

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خرید پکیج

Incidence of prolonged chemotherapy-induced amenorrhea according to age and type of adjuvant chemotherapy regimen