Association of short-acting calcium channel blockers with increased myocardial infarction risk

The relative risk of myocardial infarction (MI) according to the type of antihypertensive therapy in 623 cases and 2032 controls. The relative risk was increased in patients taking any form of calcium channel blocker (CCB), an effect that was greatest with concurrent therapy with a thiazide diuretic (Tz). There was no increase in risk with a beta blocker (β-blk) or an angiotensin converting enzyme inhibitor (ACEI). The right panel shows that the deleterious effect of calcium channel blocker therapy was seen only with moderate and high doses.