Lung function in carmustine pulmonary toxicity

Serial forced vital capacity (FVC) measurements of eight patients with late onset carmustine (BCNU) lung fibrosis confirmed by chest radiography and/or biopsies Most patients had a gradual decline in FVC during five to nine years of follow-up. The two patients with the best preserved lung function were treated in their teenage years; all except one of the other patients were treated at age 10 or less.