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Levels of hematopoietic toxicity following radiation exposure

Levels of hematopoietic toxicity following radiation exposure
Degree ALC (cells/microL) ANC (cells/microL) Platelet count (cells/microL) Bleeding and anemia
1 ≥1500 ≥2000 ≥100,000

Petechiae, bruising

Normal Hb level
2 1000 to 1500 1000 to 2000 50 to 100,000

Mild blood loss

<10% decrease in Hb
3 500 to 1000 500 to 1000 20 to 50,000

Gross blood loss

10 to 20% decrease in Hb
4 <500 <500 <20,000

Spontaneous bleeding

>20% decrease in Hb
Normal reference values: ALC 1400 to 3500 cells/microL; ANC 4000 to 9000 cells/microL; platelet count 140 to 400,000 cells/microL.
ALC: absolute lymphocyte count; ANC: absolute neutrophil count; Hb: hemoglobin concentration.
Adapted with permission from: Medical Management of Radiation Accidents: Manual on the Acute Radiation Syndrome, 1st ed, Fliedner TM, Friesecke I, Beyrer K (Eds), British Institute of Radiology 2001. Copyright © 2001 British Institute of Radiology.
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