Sulfonylureas with significant renally-eliminated, active metabolites

Sulfonylurea	Active, renally-eliminated metabolite
Acetohexamide	Hydroxyhexamide, 65 percent
Chlorpropamide	Chlorpropamide, 20 percent 2-Hydroxychlorpropamide, 55 percent
Tolazamide	Hydroxytolazamide, 35 percent Tolazamide, 7 percent
Tolbutamide	Hydroxytolbutamide, 30 percent
Glimepiride	Cyclohexylhydroxymethyl derivative, 63 percent
Glyburide	4-hydroxyglyburide, 36 percent

Sulfonylurea_renal_metab.htm

Data from: Bosse, GM. Antidiabetes and Hypoglycemics. In: Goldfrank's Toxicologic Emergencies, 8th Edition, Goldfrank, LR, Flomenbaum, NE, Hoffman, RS, et al (Eds), McGraw Hill, New York 2006. p. 749.

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