Oral ambulatory incremental regimen for patients sensitive to TMP-SMX (three doses given each day)

Day	SMX concentration (mg/mL)	Volume/dose (mL)	SMX dose/day (mg)
1	0.00002	1, then 3, then 7	0.00022
2	0.0002	1, then 3, then 7	0.0022
3	0.002	1, then 3, then 7	0.022
4	0.02	1, then 3, then 7	0.22
5	0.2	1, then 3, then 7	2.2
6	2	1, then 3, then 7	22
7	20	1, then 3, then 7	220
8	40	5, then 10, then 20	1400
9 and thereafter	One TMP-SMX DS tab (160 mg TMP-SMX 800 mg)

TMP: trimethoprim; SMX: sulfamethoxazole; DS: double-strength.

Adapted with permission from: Rich JD, Sullivan T, Greineder D, Kazanjian PH. Trimethoprim/sulfamethoxazole incremental dose regimen in human immunodeficiency virus-infected persons. Ann Allergy Asthma Immunol 1997; 79:409. Copyright ©1997 American College of Allergy, Asthma, and Immunology.

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Oral ambulatory incremental regimen for patients sensitive to TMP-SMX (three doses given each day)