Benefit of ACE inhibitors in all patients with acute MI

Reduction in deaths with the use of lisinopril or captopril (red and green bars) versus control (blue solid bars) after acute myocardial infarction in the GISSI-3 and ISIS-4 trials. The numbers in parentheses refer to the portion of mortality reduction attributable to the ACE inhibitor for each of the three time periods shown; approximately 30 percent of the total mortality reduction occurred within the first 24 hours following symptom onset, supporting the early use of these agents in acute myocardial infarction.