Version June 2024
| Controversy | Best available answer |
| For how long should patients be treated? | 12 to 18 months |
| Does the dose influence the chances of remission? | Probably not |
| Do higher doses bring the disease under more rapid control? | Yes |
| Does the coadministration or subsequent use of T4 or T3 improve remission rates? | No |
| Are there baseline predictors of the likelihood of remission? | Severe disease, large goiter, high anti-TRAb titers may be predictive of failure, but only in extreme cases |
| Does pretreatment with antithyroid drugs decrease the chances of thyroid storm or other adverse outcomes after radioiodine therapy? | Possibly, but only because thyroid hormone levels are lower after therapy in those few patients who exhibit an exacerbation |
| Will antithyroid drug therapy after radioiodine lead to more rapid disease control? | Propylthiouracil, no (at six weeks); methimazole, yes |
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