RET receptor tyrosine kinase: Effect of activating mutations

(A) Effect of Cys634Arg mutation (MEN2A).
(B) Effect of Met918Thr mutation (MEN2B).

GFRa: co-receptor glial cell line-derived neurotrophic factor-receptor family-a; TK-1: tyrosine kinase domain 1; TK-2: tyrosine kinase domain 2; MEN2A: multiple endocrine neoplasia type 2A; MEN2B: multiple endocrine neoplasia type 2B.

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