Version June 2024
| Diagnostic markers | Acute HBV/HDV coinfection | Acute HDV superinfection | Chronic HDV infection |
| HBsAg | Positive | Positive | Positive |
| Anti-HBc, IgM | Positive | Negative | Negative |
| Serum HDAg (by EIA/RIA) | Early and short-lived, frequently missed | Early and transient, and frequently missed | Not detectable |
| Serum HDV RNA (by RT-PCR) | Early, transient but last longer than HDAg | Early and persistent | Positive |
| Anti-HDV, total | Late, low titer | Rapidly increasing titers | High titers |
| Anti-HDV, IgM | Transient, may be the only marker | Rapidly increasing and persistent titers | Variable titers, usually high |
| Liver HDAg | Not indicated | Positive | Usually positive, may be negative in late stages |
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