Mechanisms of glomerular damage

Schematic depiction of the major mechanisms by which immune events lead to damage of the glomerular filtration barrier.

Th: T helper cell; IgG: immunoglobulin G; MBL: Mannan-binding lectin; MAC: membrane attack complex; GEC: glomerular epithelial cell; GEN: glomerular endothelial cell; MC: mesangial cell; GBM: glomerular basement membrane; TLR: toll-like receptors; MP: macrophage; PMN: polymorphonuclear cell; NK: natural killer cell; PLT: platelet.

Courtesy of Ramòn G.B. Bonegio, MBBCh, PhD.

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Mechanisms of glomerular damage