Adrenal pathology in disseminated neonatal herpes simplex virus (HSV) infection

Panel A) Histopathologic slide (magnification 10X) of adrenal gland of a neonate who died of disseminated HSV. Adrenal gland shows area of necrosis. Immunoperoxidase stain specific for HSV antigens shows area of HSV-associated adrenal necrosis in reddish brown. Panel B) Histopathologic slide (magnification 10X) of adrenal gland of a neonate who died of disseminated HSV. Adrenal gland shows area of necrosis.