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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
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Reported experience with deliberate delay of therapy for patients with invasive cervical cancer to allow for time for fetal maturity

Reported experience with deliberate delay of therapy for patients with invasive cervical cancer to allow for time for fetal maturity
Author, year N Stage EGA at diagnosis EGA at delivery Delay in treatment (weeks) Disease progression Follow-up (month; mean/range) Maternal outcome
Prem, 1966 4 I ≥28 35-36 6 (average) - All >60 months All NED
Prem, 1966 5 I 20-34 34-38 11-17 - 34-64 All NED
Boutselis, 1972 5 IA1 8-24 3rd trimester - - 72-180 All NED
Dudan, 1973 2 IB - - 8-24 2 - ≥1 DOD
Thompson, 1975 7 IA - 3rd trimester 5-28 - 50 (3-120) All NED
Lee, 1981 9 IA-II ≥24 3rd trimester <12 No - All NED
Nisker, 1983 1 IB - 3rd trimester 24 1 - DOD
Greer, 1989 5 IB 20-24 28-37 6-17 No 23 (13-35)

4 NED

1 DOD
Monk, 1992 4 IA2-IB 10-23 3rd trimester 10-23 No 40 (2-228) All NED
Duggan, 1993 8 IA1-IB1 11-31 31-40 8-30 No 33 (3-124) All NED
Sorosky, 1995 8 IB1 0-34* 33-38 3-40 No 33 (13-68) All NED
Sorosky, 1996 4 IB1-IB2 18-32 35-36 4-15 - 51 (12-120)

3 NED

1 DOD
Sood, 1996 11 IA1-IB1 - 3rd trimester 3-32 - 118 (12-360) All NED
Van Vliet, 1998 4 IB 23-32 32-35 3-10 - 67 (16-106) All NED
Takushi, 2002 12 IA1-IB2 12-27 30 - term 6-25 No 70-156 All NED
Taen, 2006 1 IB1 14 31 17 No 17 NED
Germann, 2005 9 IB1 1st and 2nd trimester 3rd trimester 4-24 (16) No 63 (2-168) All NED
Lee, 2007 11 IA1-IIA 6-31 - 4-34 - -

9 NED

2 DOD
Yahata, 2008 4 IA1Δ 16-23 37-41 >16-25 No 24-155 All NED
TOTAL 98 IA1-II 0-34 3rd trimester 3-40 3 2-360

93 NED

4 DOD
In some cases treatment delay was greater than the time difference of diagnosis to delivery as post-delivery irradiation may not have started for several weeks postpartum.
EGA: estimated gestational age; NED: no evidence of disease; DOD: dead of disease.
* One patient was diagnosed in the cycle prior to conception and followed through pregnancy.
¶ Excluded 3 cases that were doubly reported in Sorosky's 1995 and 1996 series.
Δ All adenocarcinoma.
Reproduced and modified with permission from: Nature Reviews. Karam A, Feldman N, Holschneider CH. Neoadjuvant cisplatin and radical cesarean hysterectomy for cervical cancer in pregnancy. Nat Clin Pract Oncol 2007; 4:375. Copyright ©2007 Macmillan Magazines Ltd.
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