Recovery of insulin secretion in NOD mice

Insulin release from isolated pancreatic islets from in 12- to 13-week-old nonobese diabetic (NOD) mice and normal mice on day 0 and day 7 in culture. Measurements were made at baseline during incubation with low glucose medium (B) and after incubation in high glucose medium (G). Insulin release from the islets from NOD mice in response to glucose was low on day 0 (second panel) but above normal by day 7 (fourth panel), suggesting the importance of in vivo inhibitory factors such as locally released cytokines.