Biopsy of a purpuric skin lesion in mixed cryoglobulinemia with PAS stain. Cryoprecipitates, which are intensely PAS-positive, can be seen occluding multiple vessels (left panel). High-power view (right panel) shows both cryoprecipitates and the deposition of fibrin in the vascular lumen and vessel wall.
PAS: periodic acid-Schiff.
Courtesy of Cynthia Magro, MD.
Graphic 54126 Version 4.0
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