Symptoms of mitochondrial dysfunction associated with antiretroviral agents

Clinical symptoms	NRTI side effects
Polyneuropathy	d4T, ddI, ddC
Myopathy	AZT
Cardiomyopathy	AZT, d4T
Hepatic steatosis, lactic acidosis	AZT, ddI, d4T
Pancreatitis	ddI
Pancytopenias	AZT
Lipodystrophy	d4T, AZT

NRTI: nucleoside reverse transcriptase inhibitor; d4T: stavudine; ddI: didanosine; ddC: zalcitabine (no longer available); AZT: zidovudine.

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