Staging classification for AIDS-related KS

	Good risk (all of the following)	Poor risk (any of the following)
Tumor, T	T0: Confined to skin and/or lymph nodes and/or minimal oral disease (non-nodular KS confined to palate)	T1:Tumor-associated edema or ulceration Extensive oral KS Gastrointestinal KS KS in other non-nodal viscera
Immune system, I	I0: CD4 cell count >200/µL*	I1: CD4 cell count <200/µL
Systemic illness, S	S0: No history of OI or thrush No "B" symptoms^Δ Karnofsky performance status >70	S1: History of OI and/or thrush "B" symptoms present Karnofsky performance status <70 Other HIV-related illness (eg, neurologic disease, lymphoma)

KS: Kaposi sarcoma; OI: opportunistic infection.
* A CD4 lymphocyte cut-off of 150 µL may be more discriminatory. (Krown, SE, Testa, MA, Huang, J. AIDS-related Kaposi's sarcoma: prospective validation of the AIDS Clinical Trials Group staging classification. AIDS Clinical Trials Group Oncology Committee. J Clin Oncol 1997; 15:3085.)
Δ "B" symptoms are unexplained fever, night sweats, >10% involuntary weight loss, or diarrhea persisting more than two weeks.

Adapted from: Krown, SE, Metroka, C, Wernz, JC. Kaposi's sarcoma in the acquired immune deficiency syndrome: a proposal for uniform evaluation, response, and staging criteria. AIDS Clinical Trials Group Oncology Committee. J Clin Oncol 1989; 7:1201.

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Staging classification for AIDS-related KS