Family history |
Major |
Familial disease confirmed at necropsy or surgery |
Minor |
Family history of premature sudden death (<35 years) caused by suspected ARVD |
Family history (clinical diagnosis based on present criteria) |
ECG depolarization/conduction abnormalities |
Major |
Epsilon waves or localized prolongation (>110 ms) of the QRS complex in the right precordial leads (V1 to V3) |
Minor |
Late potentials seen on signal averaged ECG |
Repolarization abnormalities |
Minor |
Inverted T waves in right precordial leads (V2 and V3) in people >12 years and in the absence of right bundle branch block |
Tissue characterisation of walls |
Major |
Fibrofatty replacement of myocardium on endomyocardial biopsy |
Global and/or regional dysfunction and structural alterations |
(detected by echocardiography, angiography, magnetic resonance imaging, or radionuclide scintigraphy) |
Major |
Severe dilatation and reduction of right ventricular ejection fraction with no (or only mild) left ventricular impairment |
Localized right ventricular aneurysms (akinetic or dyskinetic areas with diastolic bulging) |
Severe segmental dilatation of the right ventricle |
Minor |
Mild global right ventricular dilatation and/or ejection fraction reduction with normal left ventricle |
Mild segmental dilatation of the right ventricle |
Regional right ventricular hypokinesia |
Arrhythmias |
Minor |
Left bundle branch block type ventricular tachycardia (sustained or nonsustained) documented on ECG, Holter monitoring, or during exercise testing |
Frequent ventricular extrasystoles (more than 1000/24 h) on Holter monitoring |
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