Version May 2024
| Tumor characteristics |
| Large tumor (>2 cm) |
| Poorly defined clinical borders |
| Recurrent tumor |
| Incompletely excised (positive margins) |
| Aggressive histologic features |
| Morpheaform, micronodular, infiltrative BCC |
| Basosquamous features |
| Poorly differentiated and deeply infiltrative SCC |
| Perineural invasion |
| Chronic scar (Marjolin's ulcer) |
| Patient characteristics |
| Immunosuppressed |
| Irradiated skin |
| Genetic syndrome (eg, xeroderma pigmentosum, Gorlin or nevoid BCC) |
| Anatomic location |
| Areas where tissue preservation is essential (including eyes, nose, hands/feet, and genitalia) |
| Embryonic fusion lines (preauricular, nasolabial fold, inner canthus, and philtrum) |
| "Mask areas" of face (central face, periorbital, nose, lips) |
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