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Histologic findings in methotrexate hepatotoxicity

Spectrum of histologic changes in methotrexate hepatotoxicity includes steatosis (top left), stellate (Ito) cell hypertrophy (top right), anisonucleosis (nuclei of varying sizes, bottom left), and, on Masson stain, hepatic fibrosis (bottom right).

Courtesy of Joel M Kremer, MD.

Graphic 54948 Version 2.0

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