Clinical presentation of bleomycin-induced lung injury

Symptoms

Dyspnea (75 to 90%)

Nonproductive cough (50 to 93%)

Chest discomfort

Signs

Fever

Tachypnea

Crackles

Cyanosis

Laboratory

PFTs show reduced lung volumes and DLCO

Oximetry shows decreased oxygen saturation (at rest or on exertion); ABGs show increased alveolar-arterial oxygen gradient

No peripheral blood eosinophilia (except possibly in hypersensitivity-like reaction)

ABGs: arterial blood gases.

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