Classification of fibrinogen disorders and selected causes

Quantitative abnormalities

Congenital

Afibrinogenemia (uncommon, autosomal recessive)

Hypofibrinogenemia (autosomal dominant)

Acquired

Hypofibrinogenemia (eg, liver disease, plasma exchange therapy, consumptive coagulopathies such as DIC, hemophagocytic lymphohistiocytosis [HLH])

Hyperfibrinogenemia (eg, inflammation, neoplasia, pregnancy)

Medications (eg, fibrinolytic agents, isotretinoin, L-asparaginase, tigecycline, valproic acid)

Qualitative abnormalities

Congenital

Dysfibrinogenemia (autosomal dominant)

Hypodysfibrinogenemia (autosomal dominant)

Acquired

Liver disease

Malignancies (eg, renal carcinoma, hepatoma, multiple myeloma)

Antifibrinogen antibodies

Refer to UpToDate for details of the pathophysiology, clinical manifestations, diagnosis, and management of fibrinogen disorders.

DIC: disseminated intravascular coagulation.

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